Evaluation of an automated ultraviolet radiation device for decontamination of <it>Clostridium difficile </it>and other healthcare-associated pathogens in hospital rooms
<p>Abstract</p> <p>Background</p> <p>Environmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against <it>Clostridium difficile </it>spores, but also saf...
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doaj-740aea6b77324252afb7dbf0806bd32f2020-11-25T03:24:51ZengBMCBMC Infectious Diseases1471-23342010-07-0110119710.1186/1471-2334-10-197Evaluation of an automated ultraviolet radiation device for decontamination of <it>Clostridium difficile </it>and other healthcare-associated pathogens in hospital roomsPultz Michael JCadnum Jennifer LNerandzic Michelle MDonskey Curtis J<p>Abstract</p> <p>Background</p> <p>Environmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against <it>Clostridium difficile </it>spores, but also safe, rapid, and automated.</p> <p>Methods</p> <p>The Tru-D™ Rapid Room Disinfection device is a mobile, fully-automated room decontamination technology that utilizes ultraviolet-C irradiation to kill pathogens. We examined the efficacy of environmental disinfection using the Tru-D device in the laboratory and in rooms of hospitalized patients. Cultures for <it>C. difficile</it>, methicillin-resistant <it>Staphylococcus aureus </it>(MRSA), and vancomycin-resistant <it>Enterococcus </it>(VRE) were collected from commonly touched surfaces before and after use of Tru-D.</p> <p>Results</p> <p>On inoculated surfaces, application of Tru-D at a reflected dose of 22,000 μWs/cm<sup>2 </sup>for ~45 minutes consistently reduced recovery of <it>C. difficile </it>spores and MRSA by >2-3 log<sub>10 </sub>colony forming units (CFU)/cm<sup>2 </sup>and of VRE by >3-4 log<sub>10 </sub>CFU/cm<sup>2</sup>. Similar killing of MRSA and VRE was achieved in ~20 minutes at a reflected dose of 12,000 μWs/cm<sup>2</sup>, but killing of <it>C. difficile </it>spores was reduced. Disinfection of hospital rooms with Tru-D reduced the frequency of positive MRSA and VRE cultures by 93% and of <it>C. difficile </it>cultures by 80%. After routine hospital cleaning of the rooms of MRSA carriers, 18% of sites under the edges of bedside tables (i.e., a frequently touched site not easily amenable to manual application of disinfectant) were contaminated with MRSA, versus 0% after Tru-D (<it>P </it>< 0.001). The system required <5 minutes to set up and did not require continuous monitoring.</p> <p>Conclusions</p> <p>The Tru-D Rapid Room Disinfection device is a novel, automated, and efficient environmental disinfection technology that significantly reduces <it>C. difficile</it>, VRE and MRSA contamination on commonly touched hospital surfaces.</p> http://www.biomedcentral.com/1471-2334/10/197 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pultz Michael J Cadnum Jennifer L Nerandzic Michelle M Donskey Curtis J |
spellingShingle |
Pultz Michael J Cadnum Jennifer L Nerandzic Michelle M Donskey Curtis J Evaluation of an automated ultraviolet radiation device for decontamination of <it>Clostridium difficile </it>and other healthcare-associated pathogens in hospital rooms BMC Infectious Diseases |
author_facet |
Pultz Michael J Cadnum Jennifer L Nerandzic Michelle M Donskey Curtis J |
author_sort |
Pultz Michael J |
title |
Evaluation of an automated ultraviolet radiation device for decontamination of <it>Clostridium difficile </it>and other healthcare-associated pathogens in hospital rooms |
title_short |
Evaluation of an automated ultraviolet radiation device for decontamination of <it>Clostridium difficile </it>and other healthcare-associated pathogens in hospital rooms |
title_full |
Evaluation of an automated ultraviolet radiation device for decontamination of <it>Clostridium difficile </it>and other healthcare-associated pathogens in hospital rooms |
title_fullStr |
Evaluation of an automated ultraviolet radiation device for decontamination of <it>Clostridium difficile </it>and other healthcare-associated pathogens in hospital rooms |
title_full_unstemmed |
Evaluation of an automated ultraviolet radiation device for decontamination of <it>Clostridium difficile </it>and other healthcare-associated pathogens in hospital rooms |
title_sort |
evaluation of an automated ultraviolet radiation device for decontamination of <it>clostridium difficile </it>and other healthcare-associated pathogens in hospital rooms |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2010-07-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Environmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against <it>Clostridium difficile </it>spores, but also safe, rapid, and automated.</p> <p>Methods</p> <p>The Tru-D™ Rapid Room Disinfection device is a mobile, fully-automated room decontamination technology that utilizes ultraviolet-C irradiation to kill pathogens. We examined the efficacy of environmental disinfection using the Tru-D device in the laboratory and in rooms of hospitalized patients. Cultures for <it>C. difficile</it>, methicillin-resistant <it>Staphylococcus aureus </it>(MRSA), and vancomycin-resistant <it>Enterococcus </it>(VRE) were collected from commonly touched surfaces before and after use of Tru-D.</p> <p>Results</p> <p>On inoculated surfaces, application of Tru-D at a reflected dose of 22,000 μWs/cm<sup>2 </sup>for ~45 minutes consistently reduced recovery of <it>C. difficile </it>spores and MRSA by >2-3 log<sub>10 </sub>colony forming units (CFU)/cm<sup>2 </sup>and of VRE by >3-4 log<sub>10 </sub>CFU/cm<sup>2</sup>. Similar killing of MRSA and VRE was achieved in ~20 minutes at a reflected dose of 12,000 μWs/cm<sup>2</sup>, but killing of <it>C. difficile </it>spores was reduced. Disinfection of hospital rooms with Tru-D reduced the frequency of positive MRSA and VRE cultures by 93% and of <it>C. difficile </it>cultures by 80%. After routine hospital cleaning of the rooms of MRSA carriers, 18% of sites under the edges of bedside tables (i.e., a frequently touched site not easily amenable to manual application of disinfectant) were contaminated with MRSA, versus 0% after Tru-D (<it>P </it>< 0.001). The system required <5 minutes to set up and did not require continuous monitoring.</p> <p>Conclusions</p> <p>The Tru-D Rapid Room Disinfection device is a novel, automated, and efficient environmental disinfection technology that significantly reduces <it>C. difficile</it>, VRE and MRSA contamination on commonly touched hospital surfaces.</p> |
url |
http://www.biomedcentral.com/1471-2334/10/197 |
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