Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux
Metabolic enzymes often form supramolecular complexes to improve product yield. Here the authors use short peptide tags to create scaffold-free assemblies and synthetic metabolic nodes.
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| Language: | English |
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Nature Publishing Group
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12247-w |
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doaj-740c4576937d496e9b36026b7d7032cf2021-05-11T11:37:44ZengNature Publishing GroupNature Communications2041-17232019-09-0110111110.1038/s41467-019-12247-wModular enzyme assembly for enhanced cascade biocatalysis and metabolic fluxWei Kang0Tian Ma1Min Liu2Jiale Qu3Zhenjun Liu4Huawei Zhang5Bin Shi6Shuai Fu7Juncai Ma8Louis Tung Faat Lai9Sicong He10Jianan Qu11Shannon Wing-Ngor Au12Byung Ho Kang13Wilson Chun Yu Lau14Zixin Deng15Jiang Xia16Tiangang Liu17Department of Chemistry, The Chinese University of Hong KongKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan UniversityDepartment of Chemistry, The Chinese University of Hong KongDepartment of Chemistry, The Chinese University of Hong KongDepartment of Chemistry, The Chinese University of Hong KongSchool of Life Sciences, The Chinese University of Hong KongKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan UniversityJ1 Biotech Co., Ltd.School of Life Sciences, The Chinese University of Hong KongSchool of Life Sciences, The Chinese University of Hong KongDepartment of Electronic and Computer Engineering, Center of Systems Biology and Human Health, School of Science and Institute for Advanced Study, Hong Kong University of Science and TechnologyDepartment of Electronic and Computer Engineering, Center of Systems Biology and Human Health, School of Science and Institute for Advanced Study, Hong Kong University of Science and TechnologySchool of Life Sciences, The Chinese University of Hong KongSchool of Life Sciences, The Chinese University of Hong KongSchool of Life Sciences, The Chinese University of Hong KongKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan UniversityDepartment of Chemistry, The Chinese University of Hong KongKey Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan UniversityMetabolic enzymes often form supramolecular complexes to improve product yield. Here the authors use short peptide tags to create scaffold-free assemblies and synthetic metabolic nodes.https://doi.org/10.1038/s41467-019-12247-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wei Kang Tian Ma Min Liu Jiale Qu Zhenjun Liu Huawei Zhang Bin Shi Shuai Fu Juncai Ma Louis Tung Faat Lai Sicong He Jianan Qu Shannon Wing-Ngor Au Byung Ho Kang Wilson Chun Yu Lau Zixin Deng Jiang Xia Tiangang Liu |
| spellingShingle |
Wei Kang Tian Ma Min Liu Jiale Qu Zhenjun Liu Huawei Zhang Bin Shi Shuai Fu Juncai Ma Louis Tung Faat Lai Sicong He Jianan Qu Shannon Wing-Ngor Au Byung Ho Kang Wilson Chun Yu Lau Zixin Deng Jiang Xia Tiangang Liu Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux Nature Communications |
| author_facet |
Wei Kang Tian Ma Min Liu Jiale Qu Zhenjun Liu Huawei Zhang Bin Shi Shuai Fu Juncai Ma Louis Tung Faat Lai Sicong He Jianan Qu Shannon Wing-Ngor Au Byung Ho Kang Wilson Chun Yu Lau Zixin Deng Jiang Xia Tiangang Liu |
| author_sort |
Wei Kang |
| title |
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux |
| title_short |
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux |
| title_full |
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux |
| title_fullStr |
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux |
| title_full_unstemmed |
Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux |
| title_sort |
modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-09-01 |
| description |
Metabolic enzymes often form supramolecular complexes to improve product yield. Here the authors use short peptide tags to create scaffold-free assemblies and synthetic metabolic nodes. |
| url |
https://doi.org/10.1038/s41467-019-12247-w |
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