Focal epilepsy features in a child with Congenital Zika Syndrome
Zika virus (ZIKV) is a mosquito-borne, single-stranded DNA flavivirus that is teratogenic and neurotropic. Similar to the teratogenic effects of other TORCH infections, ZIKV infection during pregnancy can have an adverse impact on fetal and neonatal development. Epilepsy is detected in 48–96% of chi...
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2020-01-01
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doaj-7416ec9c51be4495b8422130e315ca662020-12-31T04:44:02ZengElsevierEpilepsy & Behavior Reports2589-98642020-01-0114100411Focal epilepsy features in a child with Congenital Zika SyndromePiumi Jayatilake0Vivian Oyegunle1Randall Waechter2Barbara Landon3Michelle Fernandes4Nikita Cudjoe5Roberta Evans6Trevor Noël7Calum Macpherson8Tyhiesia Donald9Samah G. Abdelbaki10Kesava Mandalaneni11Dennis Dlugos12Geetha Chari13Archana A. Patel14Elysse N. Grossi-Soyster15A. Desiree LaBeaud16Karen Blackmon17St. George’s University, St. George’s, West Indies, GrenadaSt. George’s University, St. George’s, West Indies, GrenadaSt. George’s University, St. George’s, West Indies, Grenada; Windward Islands Research and Education Foundation, St George’s University, West Indies, GrenadaWindward Islands Research and Education Foundation, St George’s University, West Indies, GrenadaFaculty of Medicine, Department of Paediatrics, University of Southampton, Southampton, UKWindward Islands Research and Education Foundation, St George’s University, West Indies, GrenadaWindward Islands Research and Education Foundation, St George’s University, West Indies, GrenadaWindward Islands Research and Education Foundation, St George’s University, West Indies, GrenadaWindward Islands Research and Education Foundation, St George’s University, West Indies, GrenadaMinistry of Health, Government of Grenada, West Indies, GrenadaBiosignal Group Inc., Acton, MA, USASt. George’s University, St. George’s, West Indies, GrenadaChildren’s Hospital of Pennsylvania, Philadelphia, PA, USASUNY Downstate Health Sciences University, New York, NY, USABoston Children’s Hospital, Division of Epilepsy and Clinical Neurophysiology, Boston, MA, USAStanford University School of Medicine, Department of Pediatrics, CA, USAStanford University School of Medicine, Department of Pediatrics, CA, USAWindward Islands Research and Education Foundation, St George’s University, West Indies, Grenada; Mayo Clinic, Jacksonville, FL, USA; Corresponding author at: Mayo Clinic Department of Psychiatry and Psychology, 4500 San Pablo Road, Jacksonville, FL 32224, USA.Zika virus (ZIKV) is a mosquito-borne, single-stranded DNA flavivirus that is teratogenic and neurotropic. Similar to the teratogenic effects of other TORCH infections, ZIKV infection during pregnancy can have an adverse impact on fetal and neonatal development. Epilepsy is detected in 48–96% of children with Congenital Zika Syndrome (CZS) and microcephaly. Early epilepsy surveillance is needed in children with prenatal ZIKV exposure; yet, most ZIKV-endemic regions do not have specialist epilepsy care. Here, we describe the demographic, clinical, imaging, and EEG characteristics of a 2-year-old child with CZS and microcephaly who presented with focal epileptiform activity, suboptimal growth, and severe neurodevelopmental delays. Administration of a brief seizure questionnaire by allied health professionals to the patient’s caregiver helped to characterize the child’s seizure semiology and differentiate focal from generalized seizure features. A telemedicine EEG interpretation platform provided valuable diagnostic information for the patient’s local pediatrician to integrate into her treatment plan. This case illustrates that CZS can present with focal epilepsy features and that a telemedicine approach can be used to bridge the gap between epilepsy specialists and local care providers in resource limited ZIKV-endemic regions to achieve better seizure control in children with CZS.http://www.sciencedirect.com/science/article/pii/S2589986420300599Congenital Zika Syndrome (CZS)MicrocephalyFocal EpilepsyElectroencephalography (EEG)Telemedicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Piumi Jayatilake Vivian Oyegunle Randall Waechter Barbara Landon Michelle Fernandes Nikita Cudjoe Roberta Evans Trevor Noël Calum Macpherson Tyhiesia Donald Samah G. Abdelbaki Kesava Mandalaneni Dennis Dlugos Geetha Chari Archana A. Patel Elysse N. Grossi-Soyster A. Desiree LaBeaud Karen Blackmon |
spellingShingle |
Piumi Jayatilake Vivian Oyegunle Randall Waechter Barbara Landon Michelle Fernandes Nikita Cudjoe Roberta Evans Trevor Noël Calum Macpherson Tyhiesia Donald Samah G. Abdelbaki Kesava Mandalaneni Dennis Dlugos Geetha Chari Archana A. Patel Elysse N. Grossi-Soyster A. Desiree LaBeaud Karen Blackmon Focal epilepsy features in a child with Congenital Zika Syndrome Epilepsy & Behavior Reports Congenital Zika Syndrome (CZS) Microcephaly Focal Epilepsy Electroencephalography (EEG) Telemedicine |
author_facet |
Piumi Jayatilake Vivian Oyegunle Randall Waechter Barbara Landon Michelle Fernandes Nikita Cudjoe Roberta Evans Trevor Noël Calum Macpherson Tyhiesia Donald Samah G. Abdelbaki Kesava Mandalaneni Dennis Dlugos Geetha Chari Archana A. Patel Elysse N. Grossi-Soyster A. Desiree LaBeaud Karen Blackmon |
author_sort |
Piumi Jayatilake |
title |
Focal epilepsy features in a child with Congenital Zika Syndrome |
title_short |
Focal epilepsy features in a child with Congenital Zika Syndrome |
title_full |
Focal epilepsy features in a child with Congenital Zika Syndrome |
title_fullStr |
Focal epilepsy features in a child with Congenital Zika Syndrome |
title_full_unstemmed |
Focal epilepsy features in a child with Congenital Zika Syndrome |
title_sort |
focal epilepsy features in a child with congenital zika syndrome |
publisher |
Elsevier |
series |
Epilepsy & Behavior Reports |
issn |
2589-9864 |
publishDate |
2020-01-01 |
description |
Zika virus (ZIKV) is a mosquito-borne, single-stranded DNA flavivirus that is teratogenic and neurotropic. Similar to the teratogenic effects of other TORCH infections, ZIKV infection during pregnancy can have an adverse impact on fetal and neonatal development. Epilepsy is detected in 48–96% of children with Congenital Zika Syndrome (CZS) and microcephaly. Early epilepsy surveillance is needed in children with prenatal ZIKV exposure; yet, most ZIKV-endemic regions do not have specialist epilepsy care. Here, we describe the demographic, clinical, imaging, and EEG characteristics of a 2-year-old child with CZS and microcephaly who presented with focal epileptiform activity, suboptimal growth, and severe neurodevelopmental delays. Administration of a brief seizure questionnaire by allied health professionals to the patient’s caregiver helped to characterize the child’s seizure semiology and differentiate focal from generalized seizure features. A telemedicine EEG interpretation platform provided valuable diagnostic information for the patient’s local pediatrician to integrate into her treatment plan. This case illustrates that CZS can present with focal epilepsy features and that a telemedicine approach can be used to bridge the gap between epilepsy specialists and local care providers in resource limited ZIKV-endemic regions to achieve better seizure control in children with CZS. |
topic |
Congenital Zika Syndrome (CZS) Microcephaly Focal Epilepsy Electroencephalography (EEG) Telemedicine |
url |
http://www.sciencedirect.com/science/article/pii/S2589986420300599 |
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