Resistance of dialyzed patients to erythropoietin
Resistance to recombinant human erythropoietin is a common condition in dialyzed patients with chronic kidney disease and is associated with more hospitalizations, increased mortality and frequent blood transfusions. The main cause of hyporesponsiveness to recombinant human erythropoietin in these p...
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2015-06-01
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Series: | Revista Brasileira de Hematologia e Hemoterapia |
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doaj-74181e5d00484133903b00041aee1b162020-11-25T02:29:58ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1806-08702015-06-0137319019710.1016/j.bjhh.2015.02.001S1516-84842015000300190Resistance of dialyzed patients to erythropoietinMichelle Teodoro AlvesSandra Simone VilaçaMaria das Graças CarvalhoAna Paula FernandesLuci Maria Sant'Ana DusseKarina Braga GomesResistance to recombinant human erythropoietin is a common condition in dialyzed patients with chronic kidney disease and is associated with more hospitalizations, increased mortality and frequent blood transfusions. The main cause of hyporesponsiveness to recombinant human erythropoietin in these patients is iron deficiency. However, a high proportion of patients does not respond to treatment, even to the use of intravenous iron, which indicates the presence of other important causes of resistance. In addition to the iron deficiency, the most common causes of resistance include inflammation, infection, malnutrition, inadequate dialysis, and hyperparathyroidism, although other factors may be associated. In the presence of adequate iron stores, other causes should be investigated and treated appropriately.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000300190&lng=en&tlng=enDialysisErythropoietinIron |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michelle Teodoro Alves Sandra Simone Vilaça Maria das Graças Carvalho Ana Paula Fernandes Luci Maria Sant'Ana Dusse Karina Braga Gomes |
spellingShingle |
Michelle Teodoro Alves Sandra Simone Vilaça Maria das Graças Carvalho Ana Paula Fernandes Luci Maria Sant'Ana Dusse Karina Braga Gomes Resistance of dialyzed patients to erythropoietin Revista Brasileira de Hematologia e Hemoterapia Dialysis Erythropoietin Iron |
author_facet |
Michelle Teodoro Alves Sandra Simone Vilaça Maria das Graças Carvalho Ana Paula Fernandes Luci Maria Sant'Ana Dusse Karina Braga Gomes |
author_sort |
Michelle Teodoro Alves |
title |
Resistance of dialyzed patients to erythropoietin |
title_short |
Resistance of dialyzed patients to erythropoietin |
title_full |
Resistance of dialyzed patients to erythropoietin |
title_fullStr |
Resistance of dialyzed patients to erythropoietin |
title_full_unstemmed |
Resistance of dialyzed patients to erythropoietin |
title_sort |
resistance of dialyzed patients to erythropoietin |
publisher |
Elsevier |
series |
Revista Brasileira de Hematologia e Hemoterapia |
issn |
1806-0870 |
publishDate |
2015-06-01 |
description |
Resistance to recombinant human erythropoietin is a common condition in dialyzed patients with chronic kidney disease and is associated with more hospitalizations, increased mortality and frequent blood transfusions. The main cause of hyporesponsiveness to recombinant human erythropoietin in these patients is iron deficiency. However, a high proportion of patients does not respond to treatment, even to the use of intravenous iron, which indicates the presence of other important causes of resistance. In addition to the iron deficiency, the most common causes of resistance include inflammation, infection, malnutrition, inadequate dialysis, and hyperparathyroidism, although other factors may be associated. In the presence of adequate iron stores, other causes should be investigated and treated appropriately. |
topic |
Dialysis Erythropoietin Iron |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000300190&lng=en&tlng=en |
work_keys_str_mv |
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