The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer developme
Colorectal cancer is one of the most common malignant tumors of the gastrointestinal tract. The development of this tumor is a complex, long-term, and multi-step process, from small dysplastic lesions of normal colorectal mucosa, through adenomatous polyps, to carcinoma in situ. Matrix metalloprotei...
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doaj-74182fda81f645188730da40420ddcba2020-11-25T02:44:56ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932010-01-01648405372230The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer developmeMagdalena GroblewskaBarbara MroczkoMaciej SzmitkowskiColorectal cancer is one of the most common malignant tumors of the gastrointestinal tract. The development of this tumor is a complex, long-term, and multi-step process, from small dysplastic lesions of normal colorectal mucosa, through adenomatous polyps, to carcinoma in situ. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in colorectal carcinogenesis. MMP-9 is able to degrade collagen IV from basement membranes and extracellular matrix, which is associated with tumor progression, including invasion, metastasis, growth, migration, and angiogenesis. It was demonstrated that increased expression of MMP-9 plays a crucial role in the development of several human malignancies, including colorectal cancer. Increased expression of MMP-9 correlated with tumor stage, invasiveness, and poor survival of colorectal cancer patients.http://journals.indexcopernicus.com/fulltxt.php?ICID=903908rak jelita grubegogruczolak jelita grubegometaloproteinazy macierzy zewnątrzkomórkowejtkankowe inhibitory metaloproteinaz |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Magdalena Groblewska Barbara Mroczko Maciej Szmitkowski |
spellingShingle |
Magdalena Groblewska Barbara Mroczko Maciej Szmitkowski The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer developme Postępy Higieny i Medycyny Doświadczalnej rak jelita grubego gruczolak jelita grubego metaloproteinazy macierzy zewnątrzkomórkowej tkankowe inhibitory metaloproteinaz |
author_facet |
Magdalena Groblewska Barbara Mroczko Maciej Szmitkowski |
author_sort |
Magdalena Groblewska |
title |
The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer developme |
title_short |
The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer developme |
title_full |
The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer developme |
title_fullStr |
The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer developme |
title_full_unstemmed |
The role of selected matrix metalloproteinases and their inhibitors in colorectal cancer developme |
title_sort |
role of selected matrix metalloproteinases and their inhibitors in colorectal cancer developme |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2010-01-01 |
description |
Colorectal cancer is one of the most common malignant tumors of the gastrointestinal tract. The development of this tumor is a complex, long-term, and multi-step process, from small dysplastic lesions of normal colorectal mucosa, through adenomatous polyps, to carcinoma in situ. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in colorectal carcinogenesis. MMP-9 is able to degrade collagen IV from basement membranes and extracellular matrix, which is associated with tumor progression, including invasion, metastasis, growth, migration, and angiogenesis. It was demonstrated that increased expression of MMP-9 plays a crucial role in the development of several human malignancies, including colorectal cancer. Increased expression of MMP-9 correlated with tumor stage, invasiveness, and poor survival of colorectal cancer patients. |
topic |
rak jelita grubego gruczolak jelita grubego metaloproteinazy macierzy zewnątrzkomórkowej tkankowe inhibitory metaloproteinaz |
url |
http://journals.indexcopernicus.com/fulltxt.php?ICID=903908 |
work_keys_str_mv |
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_version_ |
1724765074364563456 |