Three new lignan glucosides from the roots of Scutellaria baicalensis

• Main Authors: Hailin Long, Haijing Zhang, Anjun Deng, Lin Ma, Lianqiu Wu, Zhihong Li, Zhihui Zhang, Wenjie Wang, Jiandong Jiang, Hailin Qin
• Format: Article
• Language: English
• Published: Elsevier 2016-05-01
• Series: Acta Pharmaceutica Sinica B
• Subjects: Scutellaria baicalensis; Roots; Labiatae; Lignan glucoside; Baicalensinosides A–C; 3,4-Dibenzyltetrahydrofuran; Osteoprotegerin-activating activity; Anti-osteoporotic activity
• Online Access: http://www.sciencedirect.com/science/article/pii/S2211383515300538

Three new lignan glucosides, baicalensinosides A–C (1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofuran-type lignan glycoside with a mono-hydroxyl substitution at the 7′-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin (OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.