Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends
The aim of this study was to encapsulate, L-ascorbic acid, in biopolymers in order to obtain (i) enhancing its encapsulation efficiency (ii) increasing drug release ratio using different pH mediums. Microparticles based on polycaprolactone, polyethylene glycol and casein are prepared by spray drying...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sciendo
2015-12-01
|
Series: | Polish Journal of Chemical Technology |
Subjects: | |
Online Access: | https://doi.org/10.1515/pjct-2015-0065 |
id |
doaj-7423720a165d4664955acc612636baee |
---|---|
record_format |
Article |
spelling |
doaj-7423720a165d4664955acc612636baee2021-09-05T13:59:42ZengSciendoPolish Journal of Chemical Technology1899-47412015-12-01174323610.1515/pjct-2015-0065pjct-2015-0065Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblendsOzsagiroglu Erhan0Guvenilir Yuksel Avcibasi1Istanbul Technical University, Chemical and Metallurgical Engineering Faculty, Chemical Engineering Department, 34469, Maslak-Istanbul, TurkeyIstanbul Technical University, Chemical and Metallurgical Engineering Faculty, Chemical Engineering Department, 34469, Maslak-Istanbul, TurkeyThe aim of this study was to encapsulate, L-ascorbic acid, in biopolymers in order to obtain (i) enhancing its encapsulation efficiency (ii) increasing drug release ratio using different pH mediums. Microparticles based on polycaprolactone, polyethylene glycol and casein are prepared by spray drying technique. Microparticles are in vitro characterized in terms of yield of production, particle size, morphology, encapsulation efficiency, and drug release. In this manner, the importance of the study is producing of a stable and effective drug encapsulation system by PCL-PEG-CS polymer mixture by spray dryer. We achieved minimum 27.540±0.656 μm particle size with 0.512 m2/g surface area, 84.05% maximum drug loading, and 68.92% drug release ratio at pH 9.6. Release profiles are fitted to previously developed kinetic models to differentiate possible release mechanisms. The Korsmeyer–Peppas model is the best described each release scenario, and the drug release is governed by non-Fickian diffusion at pH 9.6. Our study proposed as an alternative or adjuvants for controlling release of L-ascorbic acid.https://doi.org/10.1515/pjct-2015-0065caseindrug encapsulationl-ascorbic acidpolycaprolactonepolyethylene glycolspray dryer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ozsagiroglu Erhan Guvenilir Yuksel Avcibasi |
spellingShingle |
Ozsagiroglu Erhan Guvenilir Yuksel Avcibasi Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends Polish Journal of Chemical Technology casein drug encapsulation l-ascorbic acid polycaprolactone polyethylene glycol spray dryer |
author_facet |
Ozsagiroglu Erhan Guvenilir Yuksel Avcibasi |
author_sort |
Ozsagiroglu Erhan |
title |
Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends |
title_short |
Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends |
title_full |
Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends |
title_fullStr |
Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends |
title_full_unstemmed |
Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends |
title_sort |
encapsulation of l-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends |
publisher |
Sciendo |
series |
Polish Journal of Chemical Technology |
issn |
1899-4741 |
publishDate |
2015-12-01 |
description |
The aim of this study was to encapsulate, L-ascorbic acid, in biopolymers in order to obtain (i) enhancing its encapsulation efficiency (ii) increasing drug release ratio using different pH mediums. Microparticles based on polycaprolactone, polyethylene glycol and casein are prepared by spray drying technique. Microparticles are in vitro characterized in terms of yield of production, particle size, morphology, encapsulation efficiency, and drug release. In this manner, the importance of the study is producing of a stable and effective drug encapsulation system by PCL-PEG-CS polymer mixture by spray dryer. We achieved minimum 27.540±0.656 μm particle size with 0.512 m2/g surface area, 84.05% maximum drug loading, and 68.92% drug release ratio at pH 9.6. Release profiles are fitted to previously developed kinetic models to differentiate possible release mechanisms. The Korsmeyer–Peppas model is the best described each release scenario, and the drug release is governed by non-Fickian diffusion at pH 9.6. Our study proposed as an alternative or adjuvants for controlling release of L-ascorbic acid. |
topic |
casein drug encapsulation l-ascorbic acid polycaprolactone polyethylene glycol spray dryer |
url |
https://doi.org/10.1515/pjct-2015-0065 |
work_keys_str_mv |
AT ozsagirogluerhan encapsulationoflascorbicacidviapolycaprolactonepolyethyleneglycolcaseinbioblends AT guveniliryukselavcibasi encapsulationoflascorbicacidviapolycaprolactonepolyethyleneglycolcaseinbioblends |
_version_ |
1717813195421253632 |