Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?

Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?

Entamoeba histolytica is the causative agent of human amoebiasis; it affects 50 million people worldwide and causes approximately 100,000 deaths per year. Entamoeba histolytica is an anaerobic parasite that is primarily found in the colon; however, for unknown reasons, it can become invasive, breach...

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Bibliographic Details
Main Authors: Erika Pineda, Doranda Perdomo
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Cells
Subjects:
Entamoeba histolytica
nitric oxide
oxidative stress
energetic metabolism
endoplasmic reticulum
Online Access:https://www.mdpi.com/2073-4409/6/4/44
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spelling doaj-7426748f8aec470b8f0f86fc01664d6c2020-11-24T21:48:55ZengMDPI AGCells2073-44092017-11-01644410.3390/cells6040044cells6040044Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?Erika Pineda0Doranda Perdomo1Laboratory of Fundamental Microbiology and Pathogenicity (MFP), University of Bordeaux, CNRS UMR-5234, 33000 Bordeaux, FranceLaboratory of Fundamental Microbiology and Pathogenicity (MFP), University of Bordeaux, CNRS UMR-5234, 33000 Bordeaux, FranceEntamoeba histolytica is the causative agent of human amoebiasis; it affects 50 million people worldwide and causes approximately 100,000 deaths per year. Entamoeba histolytica is an anaerobic parasite that is primarily found in the colon; however, for unknown reasons, it can become invasive, breaching the gut barrier and migrating toward the liver causing amoebic liver abscesses. During the invasive process, it must maintain intracellular hypoxia within the oxygenated human tissues and cellular homeostasis during the host immune defense attack when it is confronted with nitric oxide and reactive oxygen species. But how? This review will address the described and potential mechanisms available to counter the oxidative stress generated during invasion and the possible role that E. histolytica’s continuous endoplasmic reticulum (Eh-ER) plays during these events.https://www.mdpi.com/2073-4409/6/4/44Entamoeba histolyticanitric oxideoxidative stressenergetic metabolismendoplasmic reticulum
collection DOAJ
language English
format Article
sources DOAJ
author Erika Pineda
Doranda Perdomo
spellingShingle Erika Pineda
Doranda Perdomo
Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?
Cells
Entamoeba histolytica
nitric oxide
oxidative stress
energetic metabolism
endoplasmic reticulum
author_facet Erika Pineda
Doranda Perdomo
author_sort Erika Pineda
title Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?
title_short Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?
title_full Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?
title_fullStr Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?
title_full_unstemmed Entamoeba histolytica under Oxidative Stress: What Countermeasure Mechanisms Are in Place?
title_sort entamoeba histolytica under oxidative stress: what countermeasure mechanisms are in place?
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2017-11-01
description Entamoeba histolytica is the causative agent of human amoebiasis; it affects 50 million people worldwide and causes approximately 100,000 deaths per year. Entamoeba histolytica is an anaerobic parasite that is primarily found in the colon; however, for unknown reasons, it can become invasive, breaching the gut barrier and migrating toward the liver causing amoebic liver abscesses. During the invasive process, it must maintain intracellular hypoxia within the oxygenated human tissues and cellular homeostasis during the host immune defense attack when it is confronted with nitric oxide and reactive oxygen species. But how? This review will address the described and potential mechanisms available to counter the oxidative stress generated during invasion and the possible role that E. histolytica’s continuous endoplasmic reticulum (Eh-ER) plays during these events.
topic Entamoeba histolytica
nitric oxide
oxidative stress
energetic metabolism
endoplasmic reticulum
url https://www.mdpi.com/2073-4409/6/4/44
work_keys_str_mv AT erikapineda entamoebahistolyticaunderoxidativestresswhatcountermeasuremechanismsareinplace
AT dorandaperdomo entamoebahistolyticaunderoxidativestresswhatcountermeasuremechanismsareinplace
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