Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure
The perineuronal net (PN), a component of the neural extracellular matrix (ECM), is a dynamic structure whose expression decreases following diminished physiological activity. Here, we analyzed the effects of increased neuronal activity on the development of aggrecan, a component of the PN, in the h...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2010-09-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999611000166X |
id |
doaj-742bb761f52c433a990007b488deb286 |
---|---|
record_format |
Article |
spelling |
doaj-742bb761f52c433a990007b488deb2862021-03-20T04:59:37ZengElsevierNeurobiology of Disease1095-953X2010-09-01393439448Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizurePaulette A. McRae0Esther Baranov1Shilpa Sarode2Amy R. Brooks-Kayal3Brenda E. Porter4Division of Neurology, Department of Pediatrics at The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Corresponding author. The Children's Hospital of Philadelphia, Abramson Research Building, Room 509, 3516 Civic Center Boulevard, Philadelphia, PA 19104, USA.Division of Neurology, Department of Pediatrics at The Children's Hospital of Philadelphia, Philadelphia, PA, USADivision of Neurology, Department of Pediatrics at The Children's Hospital of Philadelphia, Philadelphia, PA, USADepartment of Pediatrics, Division of Neurology, University of Colorado, Denver School of Medicine and The Children's Hospital, Aurora CO, USADivision of Neurology, Department of Pediatrics at The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USAThe perineuronal net (PN), a component of the neural extracellular matrix (ECM), is a dynamic structure whose expression decreases following diminished physiological activity. Here, we analyzed the effects of increased neuronal activity on the development of aggrecan, a component of the PN, in the hippocampus. We show aggrecan expression to be prominent around parvalbumin (PV) interneurons in the postnatal hippocampus. Moreover, after seizure induction in early life there was a significant increase in aggrecan expression in a region specific manner during the course of development. We conclude that increased neuronal activity leads to accelerated expression of PNs in the hippocampus that attenuates in the adult hippocampus. This study shows the dynamic nature of the PN component of the ECM and the role neuronal activity has in molding the extracellular milieu of inhibitory interneurons.http://www.sciencedirect.com/science/article/pii/S096999611000166XAggrecanPerineuronal netExtracellular matrixHippocampusKainic acidNeonatal seizure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paulette A. McRae Esther Baranov Shilpa Sarode Amy R. Brooks-Kayal Brenda E. Porter |
spellingShingle |
Paulette A. McRae Esther Baranov Shilpa Sarode Amy R. Brooks-Kayal Brenda E. Porter Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure Neurobiology of Disease Aggrecan Perineuronal net Extracellular matrix Hippocampus Kainic acid Neonatal seizure |
author_facet |
Paulette A. McRae Esther Baranov Shilpa Sarode Amy R. Brooks-Kayal Brenda E. Porter |
author_sort |
Paulette A. McRae |
title |
Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure |
title_short |
Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure |
title_full |
Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure |
title_fullStr |
Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure |
title_full_unstemmed |
Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure |
title_sort |
aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2010-09-01 |
description |
The perineuronal net (PN), a component of the neural extracellular matrix (ECM), is a dynamic structure whose expression decreases following diminished physiological activity. Here, we analyzed the effects of increased neuronal activity on the development of aggrecan, a component of the PN, in the hippocampus. We show aggrecan expression to be prominent around parvalbumin (PV) interneurons in the postnatal hippocampus. Moreover, after seizure induction in early life there was a significant increase in aggrecan expression in a region specific manner during the course of development. We conclude that increased neuronal activity leads to accelerated expression of PNs in the hippocampus that attenuates in the adult hippocampus. This study shows the dynamic nature of the PN component of the ECM and the role neuronal activity has in molding the extracellular milieu of inhibitory interneurons. |
topic |
Aggrecan Perineuronal net Extracellular matrix Hippocampus Kainic acid Neonatal seizure |
url |
http://www.sciencedirect.com/science/article/pii/S096999611000166X |
work_keys_str_mv |
AT pauletteamcrae aggrecanexpressionacomponentoftheinhibitoryinterneuronperineuronalnetisalteredfollowinganearlylifeseizure AT estherbaranov aggrecanexpressionacomponentoftheinhibitoryinterneuronperineuronalnetisalteredfollowinganearlylifeseizure AT shilpasarode aggrecanexpressionacomponentoftheinhibitoryinterneuronperineuronalnetisalteredfollowinganearlylifeseizure AT amyrbrookskayal aggrecanexpressionacomponentoftheinhibitoryinterneuronperineuronalnetisalteredfollowinganearlylifeseizure AT brendaeporter aggrecanexpressionacomponentoftheinhibitoryinterneuronperineuronalnetisalteredfollowinganearlylifeseizure |
_version_ |
1724211443961692160 |