Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats
The use of nanoparticles in medicine is an attractive proposition. In the present study, zinc oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino rats with weight 120 ± 20 and age 6 months were used. Animals were grouped as follows: control; did not recei...
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doaj-743bdcfc10c949f3a843ce1fc0496ae72020-11-25T00:46:41ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-01-011522015202310.3390/ijms15022015ijms15022015Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic RatsAli Alkaladi0Aaser Mohamed Abdelazim1Mohamed Afifi2Department of Biological Sciences, Faculty of Science, King Abdulaziz University, North Campus, P.O. Box 11508, Jeddah 21463, Saudi ArabiaDepartment of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, EgyptDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, North Campus, P.O. Box 11508, Jeddah 21463, Saudi ArabiaThe use of nanoparticles in medicine is an attractive proposition. In the present study, zinc oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino rats with weight 120 ± 20 and age 6 months were used. Animals were grouped as follows: control; did not receive any type of treatment, diabetic; received a single intraperitoneal dose of streptozotocin (100 mg/kg), diabetic + zinc oxide nanoparticles (ZnONPs), received single daily oral dose of 10 mg/kg ZnONPs in suspension, diabetic + silver nanoparticles (SNPs); received a single daily oral dose of SNP of 10 mg/kg in suspension and diabetic + insulin; received a single subcutaneous dose of 0.6 units/50 g body weight. Zinc oxide and silver nanoparticles induce a significant reduced blood glucose, higher serum insulin, higher glucokinase activity higher expression level of insulin, insulin receptor, GLUT-2 and glucokinase genes in diabetic rats treated with zinc oxide, silver nanoparticles and insulin. In conclusion, zinc oxide and sliver nanoparticles act as potent antidiabetic agents.http://www.mdpi.com/1422-0067/15/2/2015diabetesZnONPsSNPs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ali Alkaladi Aaser Mohamed Abdelazim Mohamed Afifi |
spellingShingle |
Ali Alkaladi Aaser Mohamed Abdelazim Mohamed Afifi Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats International Journal of Molecular Sciences diabetes ZnONPs SNPs |
author_facet |
Ali Alkaladi Aaser Mohamed Abdelazim Mohamed Afifi |
author_sort |
Ali Alkaladi |
title |
Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats |
title_short |
Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats |
title_full |
Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats |
title_fullStr |
Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats |
title_full_unstemmed |
Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats |
title_sort |
antidiabetic activity of zinc oxide and silver nanoparticles on streptozotocin-induced diabetic rats |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2014-01-01 |
description |
The use of nanoparticles in medicine is an attractive proposition. In the present study, zinc oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino rats with weight 120 ± 20 and age 6 months were used. Animals were grouped as follows: control; did not receive any type of treatment, diabetic; received a single intraperitoneal dose of streptozotocin (100 mg/kg), diabetic + zinc oxide nanoparticles (ZnONPs), received single daily oral dose of 10 mg/kg ZnONPs in suspension, diabetic + silver nanoparticles (SNPs); received a single daily oral dose of SNP of 10 mg/kg in suspension and diabetic + insulin; received a single subcutaneous dose of 0.6 units/50 g body weight. Zinc oxide and silver nanoparticles induce a significant reduced blood glucose, higher serum insulin, higher glucokinase activity higher expression level of insulin, insulin receptor, GLUT-2 and glucokinase genes in diabetic rats treated with zinc oxide, silver nanoparticles and insulin. In conclusion, zinc oxide and sliver nanoparticles act as potent antidiabetic agents. |
topic |
diabetes ZnONPs SNPs |
url |
http://www.mdpi.com/1422-0067/15/2/2015 |
work_keys_str_mv |
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