Multifaceted role of Matrix Metalloproteinases (MMPs)

• Main Authors: Divya eSingh, Sanjeev Kumar Srivastava, Tapas K Chaudhuri, Ghanshyam eUpadhyay
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2015-05-01
• Series: Frontiers in Molecular Biosciences
• Subjects: Glaucoma; Neurodegenerative disorders; Japanese encephalitis; MMP2; MMP9
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00019/full

Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved the tissue remodeling and degradation of the extracellular matrix. MMPs are widely distributed in brain and regulate various processes including microglial activation, inflammation, dopaminergic apoptosis, blood brain barrier disruption and modulation of α-synuclein pathology. High expression of MMPs is well documented in various neurological disorders including Parkinson’s disease (PD), Alzheimer’s disease (AD), Japanese encephalitis (JE) and Glaucoma. Although potentially critical, the role of MMPs in neuronal disorders is under investigated. The present review summarizes the role of MMPs in neurodegeneration with a particular emphasis on PD, AD, JE and Glaucoma.