THE ROLE OF ENDOTHELIAL DYSFUNCTION AND ARTERIAL RIGIDITY IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Chronic obstructive pulmonary disease (COPD) is a disease with progressive dysfunction of external respiration due to inflammatory reaction of pulmonary tissue to irritation by different pathogenic agents and gases. According to population-based studies, COPD patients have a 2-3-fold higher risk of...
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"Consilium Medicum" Publishing house
2012-03-01
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doaj-7459187816ad48e5854ef9f87a75a7c32020-11-25T03:12:42Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422012-03-01843748028046THE ROLE OF ENDOTHELIAL DYSFUNCTION AND ARTERIAL RIGIDITY IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASEM A Makarova0S N Avdeev1A G Chuchalin2Research Institute of PulmonologyResearch Institute of PulmonologyResearch Institute of PulmonologyChronic obstructive pulmonary disease (COPD) is a disease with progressive dysfunction of external respiration due to inflammatory reaction of pulmonary tissue to irritation by different pathogenic agents and gases. According to population-based studies, COPD patients have a 2-3-fold higher risk of cardiovascular death, while the number of lethal outcomes comprise about 50% of total number of deaths. As shown by the evidence from studies, COPD patients demonstrate high arterial rigidity and endothelial dysfunction. It is important that these changes can be corrected with pharmacological and non-pharmacological impacts. Examination of structural-functional vascular changes in COPD patients is of great clinicoprognostic importance and can modify therapeutic and prophylactic approaches to COPD.https://ter-arkhiv.ru/0040-3660/article/view/31030copdendothelial dysfunctionarterial rigiditycardiovascular diseases |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
M A Makarova S N Avdeev A G Chuchalin |
spellingShingle |
M A Makarova S N Avdeev A G Chuchalin THE ROLE OF ENDOTHELIAL DYSFUNCTION AND ARTERIAL RIGIDITY IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE Терапевтический архив copd endothelial dysfunction arterial rigidity cardiovascular diseases |
author_facet |
M A Makarova S N Avdeev A G Chuchalin |
author_sort |
M A Makarova |
title |
THE ROLE OF ENDOTHELIAL DYSFUNCTION AND ARTERIAL RIGIDITY IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
title_short |
THE ROLE OF ENDOTHELIAL DYSFUNCTION AND ARTERIAL RIGIDITY IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
title_full |
THE ROLE OF ENDOTHELIAL DYSFUNCTION AND ARTERIAL RIGIDITY IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
title_fullStr |
THE ROLE OF ENDOTHELIAL DYSFUNCTION AND ARTERIAL RIGIDITY IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
title_full_unstemmed |
THE ROLE OF ENDOTHELIAL DYSFUNCTION AND ARTERIAL RIGIDITY IN PATHOGENESIS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
title_sort |
role of endothelial dysfunction and arterial rigidity in pathogenesis of chronic obstructive pulmonary disease |
publisher |
"Consilium Medicum" Publishing house |
series |
Терапевтический архив |
issn |
0040-3660 2309-5342 |
publishDate |
2012-03-01 |
description |
Chronic obstructive pulmonary disease (COPD) is a disease with progressive dysfunction of external respiration due to inflammatory reaction of pulmonary tissue to irritation by different pathogenic agents and gases. According to population-based studies, COPD patients have a 2-3-fold higher risk of cardiovascular death, while the number of lethal outcomes comprise about 50% of total number of deaths. As shown by the evidence from studies, COPD patients demonstrate high arterial rigidity and endothelial dysfunction. It is important that these changes can be corrected with pharmacological and non-pharmacological impacts. Examination of structural-functional vascular changes in COPD patients is of great clinicoprognostic importance and can modify therapeutic and prophylactic approaches to COPD. |
topic |
copd endothelial dysfunction arterial rigidity cardiovascular diseases |
url |
https://ter-arkhiv.ru/0040-3660/article/view/31030 |
work_keys_str_mv |
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