Pathophysiological Aspects of Alcohol Metabolism in the Liver
Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; therefore, it is particularly sensitive to alcohol intake. Metabolites and byproducts generated during alcohol metabol...
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doaj-7464c14a43344b9392315f6da805247f2021-06-01T01:18:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01225717571710.3390/ijms22115717Pathophysiological Aspects of Alcohol Metabolism in the LiverJeongeun Hyun0Jinsol Han1Chanbin Lee2Myunghee Yoon3Youngmi Jung4Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, KoreaDepartment of Integrated Biological Science, Pusan National University, Pusan 46241, KoreaDepartment of Integrated Biological Science, Pusan National University, Pusan 46241, KoreaDepartment of Surgery, Division of Hepatobiliary and Pancreas Surgery, Biomedical Research Institute, Pusan National University, Pusan 46241, KoreaDepartment of Integrated Biological Science, Pusan National University, Pusan 46241, KoreaAlcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; therefore, it is particularly sensitive to alcohol intake. Metabolites and byproducts generated during alcohol metabolism cause liver damage, leading to ALD via several mechanisms, such as impairing lipid metabolism, intensifying inflammatory reactions, and inducing fibrosis. Despite the severity of ALD, the development of novel treatments has been hampered by the lack of animal models that fully mimic human ALD. To overcome the current limitations of ALD studies and therapy development, it is necessary to understand the molecular mechanisms underlying alcohol-induced liver injury. Hence, to provide insights into the progression of ALD, this review examines previous studies conducted on alcohol metabolism in the liver. There is a particular focus on the occurrence of ALD caused by hepatotoxicity originating from alcohol metabolism.https://www.mdpi.com/1422-0067/22/11/5717alcoholic liver diseasealcohol metabolismlipotoxicityinflammationfibrosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeongeun Hyun Jinsol Han Chanbin Lee Myunghee Yoon Youngmi Jung |
spellingShingle |
Jeongeun Hyun Jinsol Han Chanbin Lee Myunghee Yoon Youngmi Jung Pathophysiological Aspects of Alcohol Metabolism in the Liver International Journal of Molecular Sciences alcoholic liver disease alcohol metabolism lipotoxicity inflammation fibrosis |
author_facet |
Jeongeun Hyun Jinsol Han Chanbin Lee Myunghee Yoon Youngmi Jung |
author_sort |
Jeongeun Hyun |
title |
Pathophysiological Aspects of Alcohol Metabolism in the Liver |
title_short |
Pathophysiological Aspects of Alcohol Metabolism in the Liver |
title_full |
Pathophysiological Aspects of Alcohol Metabolism in the Liver |
title_fullStr |
Pathophysiological Aspects of Alcohol Metabolism in the Liver |
title_full_unstemmed |
Pathophysiological Aspects of Alcohol Metabolism in the Liver |
title_sort |
pathophysiological aspects of alcohol metabolism in the liver |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-05-01 |
description |
Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic or binge consumption of alcohol. The liver is the major organ that metabolizes alcohol; therefore, it is particularly sensitive to alcohol intake. Metabolites and byproducts generated during alcohol metabolism cause liver damage, leading to ALD via several mechanisms, such as impairing lipid metabolism, intensifying inflammatory reactions, and inducing fibrosis. Despite the severity of ALD, the development of novel treatments has been hampered by the lack of animal models that fully mimic human ALD. To overcome the current limitations of ALD studies and therapy development, it is necessary to understand the molecular mechanisms underlying alcohol-induced liver injury. Hence, to provide insights into the progression of ALD, this review examines previous studies conducted on alcohol metabolism in the liver. There is a particular focus on the occurrence of ALD caused by hepatotoxicity originating from alcohol metabolism. |
topic |
alcoholic liver disease alcohol metabolism lipotoxicity inflammation fibrosis |
url |
https://www.mdpi.com/1422-0067/22/11/5717 |
work_keys_str_mv |
AT jeongeunhyun pathophysiologicalaspectsofalcoholmetabolismintheliver AT jinsolhan pathophysiologicalaspectsofalcoholmetabolismintheliver AT chanbinlee pathophysiologicalaspectsofalcoholmetabolismintheliver AT myungheeyoon pathophysiologicalaspectsofalcoholmetabolismintheliver AT youngmijung pathophysiologicalaspectsofalcoholmetabolismintheliver |
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1721412657734483968 |