Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study
Protein supplements are usually used to control body weight, however, the impact of protein quality on body fat attenuation is unknown. We investigated the effects of isocaloric isoproteic supplementation of either whey protein (WG) or hydrolysed collagen supplementation (CG) on dietary intake, adip...
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doaj-746e7402d2f2448692315b6fa60ab1c32020-11-25T02:01:12ZengMDPI AGNutrients2072-66432019-09-01119205110.3390/nu11092051nu11092051Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind StudyBruna M. Giglio0Raquel M. Schincaglia1Alexandre S. da Silva2Ieda C. S. Fazani3Paula A. Monteiro4João F. Mota5Juliana P. Cunha6Claude Pichard7Gustavo D. Pimentel8Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilClinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilClinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilClinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilExercise and Immunometabolism Research Group, Postgraduation Program in Movement Sciences, Department of Physical Education, Universidade Estadual Paulista, Presidente Prudente, São Paulo 19060-900, BrazilClinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilClinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilClinical Nutrition, Geneva University Hospital, 1205 Geneva, SwitzerlandClinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia 74605-080, BrazilProtein supplements are usually used to control body weight, however, the impact of protein quality on body fat attenuation is unknown. We investigated the effects of isocaloric isoproteic supplementation of either whey protein (WG) or hydrolysed collagen supplementation (CG) on dietary intake, adiposity and biochemical markers in overweight women. Methods: In this randomized double-blind study, 37 women, [mean ± SE, age 40.6 ± 1.7 year; BMI (kg/m<sup>2</sup>) 30.9 ± 0.6], consumed sachets containing 40 g/day of concentrated whey protein (25 g total protein, 2.4 leucine, 1.0 valine, 1.5 isoleucine, <i>n</i> = 17) or 38 g/day of hydrolysed collagen (26 g total protein, 1.02 leucine, 0.91 valine, 0.53 isoleucine, <i>n</i> = 20) in the afternoon snack. The compliance was set at >70% of the total theoretical doses. The dietary intake was evaluated by a 6-day food record questionnaire. At the beginning and after eight weeks of follow-up, body composition was evaluated by using dual-energy X-ray absorptiometry and lipid profile, insulin resistance, C-reactive protein, adiponectin, leptin and nesfastin plasma concentrations were analyzed. Results: Supplements were isocaloric and isoproteic. There were no differences in caloric intake (<i>p</i> = 0.103), protein (<i>p</i> = 0.085), carbohydrate (<i>p</i> = 0.797) and lipids (<i>p</i> = 0.109) intakes. The branched chain amino acids (BCAA) (GC: 1.8 ± 0.1 g vs. WG: 5.5 ± 0.3 g, <i>p</i> < 0.001) and leucine intake (CG: 0.1 ± 0.1 g vs. WG: 2.6 ± 0.1 g, <i>p</i> < 0.001) were higher in WG compared to CG. BMI increased in the CG (0.2 ± 1.1 kg/m<sup>2</sup>, <i>p</i> = 0.044) but did not change in WG. WG decreased the android fat (−0.1 ± 0.3 kg, <i>p</i> = 0.031) and increased nesfatin concentrations (4.9 ± 3.2 ng/mL, <i>p</i> = 0.014) compared to CG. Conclusions: Whey protein supplementation in overweight women increased nesfatin concentrations and could promote increase of resting metabolic rate as part of body composition improvement programs compared to collagen supplementation for 8 weeks. Additionally, our findings suggest that collagen may not be an effective supplement for overweight women who are attempting to alter body composition.https://www.mdpi.com/2072-6643/11/9/2051obesitywhey proteincollagenweight lossleucineamino acids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bruna M. Giglio Raquel M. Schincaglia Alexandre S. da Silva Ieda C. S. Fazani Paula A. Monteiro João F. Mota Juliana P. Cunha Claude Pichard Gustavo D. Pimentel |
spellingShingle |
Bruna M. Giglio Raquel M. Schincaglia Alexandre S. da Silva Ieda C. S. Fazani Paula A. Monteiro João F. Mota Juliana P. Cunha Claude Pichard Gustavo D. Pimentel Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study Nutrients obesity whey protein collagen weight loss leucine amino acids |
author_facet |
Bruna M. Giglio Raquel M. Schincaglia Alexandre S. da Silva Ieda C. S. Fazani Paula A. Monteiro João F. Mota Juliana P. Cunha Claude Pichard Gustavo D. Pimentel |
author_sort |
Bruna M. Giglio |
title |
Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study |
title_short |
Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study |
title_full |
Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study |
title_fullStr |
Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study |
title_full_unstemmed |
Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study |
title_sort |
whey protein supplementation compared to collagen increases blood nesfatin concentrations and decreases android fat in overweight women: a randomized double-blind study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-09-01 |
description |
Protein supplements are usually used to control body weight, however, the impact of protein quality on body fat attenuation is unknown. We investigated the effects of isocaloric isoproteic supplementation of either whey protein (WG) or hydrolysed collagen supplementation (CG) on dietary intake, adiposity and biochemical markers in overweight women. Methods: In this randomized double-blind study, 37 women, [mean ± SE, age 40.6 ± 1.7 year; BMI (kg/m<sup>2</sup>) 30.9 ± 0.6], consumed sachets containing 40 g/day of concentrated whey protein (25 g total protein, 2.4 leucine, 1.0 valine, 1.5 isoleucine, <i>n</i> = 17) or 38 g/day of hydrolysed collagen (26 g total protein, 1.02 leucine, 0.91 valine, 0.53 isoleucine, <i>n</i> = 20) in the afternoon snack. The compliance was set at >70% of the total theoretical doses. The dietary intake was evaluated by a 6-day food record questionnaire. At the beginning and after eight weeks of follow-up, body composition was evaluated by using dual-energy X-ray absorptiometry and lipid profile, insulin resistance, C-reactive protein, adiponectin, leptin and nesfastin plasma concentrations were analyzed. Results: Supplements were isocaloric and isoproteic. There were no differences in caloric intake (<i>p</i> = 0.103), protein (<i>p</i> = 0.085), carbohydrate (<i>p</i> = 0.797) and lipids (<i>p</i> = 0.109) intakes. The branched chain amino acids (BCAA) (GC: 1.8 ± 0.1 g vs. WG: 5.5 ± 0.3 g, <i>p</i> < 0.001) and leucine intake (CG: 0.1 ± 0.1 g vs. WG: 2.6 ± 0.1 g, <i>p</i> < 0.001) were higher in WG compared to CG. BMI increased in the CG (0.2 ± 1.1 kg/m<sup>2</sup>, <i>p</i> = 0.044) but did not change in WG. WG decreased the android fat (−0.1 ± 0.3 kg, <i>p</i> = 0.031) and increased nesfatin concentrations (4.9 ± 3.2 ng/mL, <i>p</i> = 0.014) compared to CG. Conclusions: Whey protein supplementation in overweight women increased nesfatin concentrations and could promote increase of resting metabolic rate as part of body composition improvement programs compared to collagen supplementation for 8 weeks. Additionally, our findings suggest that collagen may not be an effective supplement for overweight women who are attempting to alter body composition. |
topic |
obesity whey protein collagen weight loss leucine amino acids |
url |
https://www.mdpi.com/2072-6643/11/9/2051 |
work_keys_str_mv |
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