Megahertz serial crystallography
The new European X-Ray Free-Electron Laser (EuXFEL) is the first XFEL that generates X-ray pulses with a megahertz inter-pulse spacing. Here the authors demonstrate that high-quality and damage-free protein structures can be obtained with the currently available 1.1 MHz repetition rate pulses using...
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Format: | Article |
Language: | English |
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Nature Publishing Group
2018-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-06156-7 |
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English |
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author |
Max O. Wiedorn Dominik Oberthür Richard Bean Robin Schubert Nadine Werner Brian Abbey Martin Aepfelbacher Luigi Adriano Aschkan Allahgholi Nasser Al-Qudami Jakob Andreasson Steve Aplin Salah Awel Kartik Ayyer Saša Bajt Imrich Barák Sadia Bari Johan Bielecki Sabine Botha Djelloul Boukhelef Wolfgang Brehm Sandor Brockhauser Igor Cheviakov Matthew A. Coleman Francisco Cruz-Mazo Cyril Danilevski Connie Darmanin R. Bruce Doak Martin Domaracky Katerina Dörner Yang Du Hans Fangohr Holger Fleckenstein Matthias Frank Petra Fromme Alfonso M. Gañán-Calvo Yaroslav Gevorkov Klaus Giewekemeyer Helen Mary Ginn Heinz Graafsma Rita Graceffa Dominic Greiffenberg Lars Gumprecht Peter Göttlicher Janos Hajdu Steffen Hauf Michael Heymann Susannah Holmes Daniel A. Horke Mark S. Hunter Siegfried Imlau Alexander Kaukher Yoonhee Kim Alexander Klyuev Juraj Knoška Bostjan Kobe Manuela Kuhn Christopher Kupitz Jochen Küpper Janine Mia Lahey-Rudolph Torsten Laurus Karoline Le Cong Romain Letrun P. Lourdu Xavier Luis Maia Filipe R. N. C. Maia Valerio Mariani Marc Messerschmidt Markus Metz Davide Mezza Thomas Michelat Grant Mills Diana C. F. Monteiro Andrew Morgan Kerstin Mühlig Anna Munke Astrid Münnich Julia Nette Keith A. Nugent Theresa Nuguid Allen M. Orville Suraj Pandey Gisel Pena Pablo Villanueva-Perez Jennifer Poehlsen Gianpietro Previtali Lars Redecke Winnie Maria Riekehr Holger Rohde Adam Round Tatiana Safenreiter Iosifina Sarrou Tokushi Sato Marius Schmidt Bernd Schmitt Robert Schönherr Joachim Schulz Jonas A. Sellberg M. Marvin Seibert Carolin Seuring Megan L. Shelby Robert L. Shoeman Marcin Sikorski Alessandro Silenzi Claudiu A. Stan Xintian Shi Stephan Stern Jola Sztuk-Dambietz Janusz Szuba Aleksandra Tolstikova Martin Trebbin Ulrich Trunk Patrik Vagovic Thomas Ve Britta Weinhausen Thomas A. White Krzysztof Wrona Chen Xu Oleksandr Yefanov Nadia Zatsepin Jiaguo Zhang Markus Perbandt Adrian P. Mancuso Christian Betzel Henry Chapman Anton Barty |
spellingShingle |
Max O. Wiedorn Dominik Oberthür Richard Bean Robin Schubert Nadine Werner Brian Abbey Martin Aepfelbacher Luigi Adriano Aschkan Allahgholi Nasser Al-Qudami Jakob Andreasson Steve Aplin Salah Awel Kartik Ayyer Saša Bajt Imrich Barák Sadia Bari Johan Bielecki Sabine Botha Djelloul Boukhelef Wolfgang Brehm Sandor Brockhauser Igor Cheviakov Matthew A. Coleman Francisco Cruz-Mazo Cyril Danilevski Connie Darmanin R. Bruce Doak Martin Domaracky Katerina Dörner Yang Du Hans Fangohr Holger Fleckenstein Matthias Frank Petra Fromme Alfonso M. Gañán-Calvo Yaroslav Gevorkov Klaus Giewekemeyer Helen Mary Ginn Heinz Graafsma Rita Graceffa Dominic Greiffenberg Lars Gumprecht Peter Göttlicher Janos Hajdu Steffen Hauf Michael Heymann Susannah Holmes Daniel A. Horke Mark S. Hunter Siegfried Imlau Alexander Kaukher Yoonhee Kim Alexander Klyuev Juraj Knoška Bostjan Kobe Manuela Kuhn Christopher Kupitz Jochen Küpper Janine Mia Lahey-Rudolph Torsten Laurus Karoline Le Cong Romain Letrun P. Lourdu Xavier Luis Maia Filipe R. N. C. Maia Valerio Mariani Marc Messerschmidt Markus Metz Davide Mezza Thomas Michelat Grant Mills Diana C. F. Monteiro Andrew Morgan Kerstin Mühlig Anna Munke Astrid Münnich Julia Nette Keith A. Nugent Theresa Nuguid Allen M. Orville Suraj Pandey Gisel Pena Pablo Villanueva-Perez Jennifer Poehlsen Gianpietro Previtali Lars Redecke Winnie Maria Riekehr Holger Rohde Adam Round Tatiana Safenreiter Iosifina Sarrou Tokushi Sato Marius Schmidt Bernd Schmitt Robert Schönherr Joachim Schulz Jonas A. Sellberg M. Marvin Seibert Carolin Seuring Megan L. Shelby Robert L. Shoeman Marcin Sikorski Alessandro Silenzi Claudiu A. Stan Xintian Shi Stephan Stern Jola Sztuk-Dambietz Janusz Szuba Aleksandra Tolstikova Martin Trebbin Ulrich Trunk Patrik Vagovic Thomas Ve Britta Weinhausen Thomas A. White Krzysztof Wrona Chen Xu Oleksandr Yefanov Nadia Zatsepin Jiaguo Zhang Markus Perbandt Adrian P. Mancuso Christian Betzel Henry Chapman Anton Barty Megahertz serial crystallography Nature Communications |
author_facet |
Max O. Wiedorn Dominik Oberthür Richard Bean Robin Schubert Nadine Werner Brian Abbey Martin Aepfelbacher Luigi Adriano Aschkan Allahgholi Nasser Al-Qudami Jakob Andreasson Steve Aplin Salah Awel Kartik Ayyer Saša Bajt Imrich Barák Sadia Bari Johan Bielecki Sabine Botha Djelloul Boukhelef Wolfgang Brehm Sandor Brockhauser Igor Cheviakov Matthew A. Coleman Francisco Cruz-Mazo Cyril Danilevski Connie Darmanin R. Bruce Doak Martin Domaracky Katerina Dörner Yang Du Hans Fangohr Holger Fleckenstein Matthias Frank Petra Fromme Alfonso M. Gañán-Calvo Yaroslav Gevorkov Klaus Giewekemeyer Helen Mary Ginn Heinz Graafsma Rita Graceffa Dominic Greiffenberg Lars Gumprecht Peter Göttlicher Janos Hajdu Steffen Hauf Michael Heymann Susannah Holmes Daniel A. Horke Mark S. Hunter Siegfried Imlau Alexander Kaukher Yoonhee Kim Alexander Klyuev Juraj Knoška Bostjan Kobe Manuela Kuhn Christopher Kupitz Jochen Küpper Janine Mia Lahey-Rudolph Torsten Laurus Karoline Le Cong Romain Letrun P. Lourdu Xavier Luis Maia Filipe R. N. C. Maia Valerio Mariani Marc Messerschmidt Markus Metz Davide Mezza Thomas Michelat Grant Mills Diana C. F. Monteiro Andrew Morgan Kerstin Mühlig Anna Munke Astrid Münnich Julia Nette Keith A. Nugent Theresa Nuguid Allen M. Orville Suraj Pandey Gisel Pena Pablo Villanueva-Perez Jennifer Poehlsen Gianpietro Previtali Lars Redecke Winnie Maria Riekehr Holger Rohde Adam Round Tatiana Safenreiter Iosifina Sarrou Tokushi Sato Marius Schmidt Bernd Schmitt Robert Schönherr Joachim Schulz Jonas A. Sellberg M. Marvin Seibert Carolin Seuring Megan L. Shelby Robert L. Shoeman Marcin Sikorski Alessandro Silenzi Claudiu A. Stan Xintian Shi Stephan Stern Jola Sztuk-Dambietz Janusz Szuba Aleksandra Tolstikova Martin Trebbin Ulrich Trunk Patrik Vagovic Thomas Ve Britta Weinhausen Thomas A. White Krzysztof Wrona Chen Xu Oleksandr Yefanov Nadia Zatsepin Jiaguo Zhang Markus Perbandt Adrian P. Mancuso Christian Betzel Henry Chapman Anton Barty |
author_sort |
Max O. Wiedorn |
title |
Megahertz serial crystallography |
title_short |
Megahertz serial crystallography |
title_full |
Megahertz serial crystallography |
title_fullStr |
Megahertz serial crystallography |
title_full_unstemmed |
Megahertz serial crystallography |
title_sort |
megahertz serial crystallography |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-10-01 |
description |
The new European X-Ray Free-Electron Laser (EuXFEL) is the first XFEL that generates X-ray pulses with a megahertz inter-pulse spacing. Here the authors demonstrate that high-quality and damage-free protein structures can be obtained with the currently available 1.1 MHz repetition rate pulses using lysozyme as a test case and furthermore present a β-lactamase structure. |
url |
https://doi.org/10.1038/s41467-018-06156-7 |
work_keys_str_mv |
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doaj-748096d642ff4fc19840f7122cfc89d32021-05-11T10:24:29ZengNature Publishing GroupNature Communications2041-17232018-10-019111110.1038/s41467-018-06156-7Megahertz serial crystallographyMax O. Wiedorn0Dominik Oberthür1Richard Bean2Robin Schubert3Nadine Werner4Brian Abbey5Martin Aepfelbacher6Luigi Adriano7Aschkan Allahgholi8Nasser Al-Qudami9Jakob Andreasson10Steve Aplin11Salah Awel12Kartik Ayyer13Saša Bajt14Imrich Barák15Sadia Bari16Johan Bielecki17Sabine Botha18Djelloul Boukhelef19Wolfgang Brehm20Sandor Brockhauser21Igor Cheviakov22Matthew A. Coleman23Francisco Cruz-Mazo24Cyril Danilevski25Connie Darmanin26R. Bruce Doak27Martin Domaracky28Katerina Dörner29Yang Du30Hans Fangohr31Holger Fleckenstein32Matthias Frank33Petra Fromme34Alfonso M. Gañán-Calvo35Yaroslav Gevorkov36Klaus Giewekemeyer37Helen Mary Ginn38Heinz Graafsma39Rita Graceffa40Dominic Greiffenberg41Lars Gumprecht42Peter Göttlicher43Janos Hajdu44Steffen Hauf45Michael Heymann46Susannah Holmes47Daniel A. Horke48Mark S. Hunter49Siegfried Imlau50Alexander Kaukher51Yoonhee Kim52Alexander Klyuev53Juraj Knoška54Bostjan Kobe55Manuela Kuhn56Christopher Kupitz57Jochen Küpper58Janine Mia Lahey-Rudolph59Torsten Laurus60Karoline Le Cong61Romain Letrun62P. Lourdu Xavier63Luis Maia64Filipe R. N. C. Maia65Valerio Mariani66Marc Messerschmidt67Markus Metz68Davide Mezza69Thomas Michelat70Grant Mills71Diana C. F. Monteiro72Andrew Morgan73Kerstin Mühlig74Anna Munke75Astrid Münnich76Julia Nette77Keith A. Nugent78Theresa Nuguid79Allen M. Orville80Suraj Pandey81Gisel Pena82Pablo Villanueva-Perez83Jennifer Poehlsen84Gianpietro Previtali85Lars Redecke86Winnie Maria Riekehr87Holger Rohde88Adam Round89Tatiana Safenreiter90Iosifina Sarrou91Tokushi Sato92Marius Schmidt93Bernd Schmitt94Robert Schönherr95Joachim Schulz96Jonas A. Sellberg97M. Marvin Seibert98Carolin Seuring99Megan L. Shelby100Robert L. Shoeman101Marcin Sikorski102Alessandro Silenzi103Claudiu A. Stan104Xintian Shi105Stephan Stern106Jola Sztuk-Dambietz107Janusz Szuba108Aleksandra Tolstikova109Martin Trebbin110Ulrich Trunk111Patrik Vagovic112Thomas Ve113Britta Weinhausen114Thomas A. White115Krzysztof Wrona116Chen Xu117Oleksandr Yefanov118Nadia Zatsepin119Jiaguo Zhang120Markus Perbandt121Adrian P. Mancuso122Christian Betzel123Henry Chapman124Anton Barty125Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHThe Hamburg Center for Ultrafast Imaging, Universität HamburgInstitute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität HamburgAustralian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe UniversityInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE)Deutsches Elektronen-Synchrotron DESYDeutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala UniversityCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYDeutsches Elektronen-Synchrotron DESYInstitute of Molecular Biology, SASDeutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHThe Hamburg Center for Ultrafast Imaging, Universität HamburgEuropean XFEL GmbHCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE)Lawrence Livermore National LaboratoryDepart. Ingeniería Aeroespacial y Mecánica de Fluidos ETSI, Universidad de SevillaEuropean XFEL GmbHAustralian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe UniversityMax Planck Institute for Medical ResearchCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYLawrence Livermore National LaboratorySchool of Molecular Sciences and Biodesign Center for Applied Structural Discovery, Arizona State UniversityDepart. Ingeniería Aeroespacial y Mecánica de Fluidos ETSI, Universidad de SevillaCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHDivision of Structural Biology, HeadingtonDeutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHPaul Scherrer InstitutCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYDeutsches Elektronen-Synchrotron DESYLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala UniversityEuropean XFEL GmbHDepartment of Cellular and Molecular Biophysics, Max Planck Institute of BiochemistryAustralian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe UniversityCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYLinac Coherent Light Source, SLAC National Accelerator LaboratoryCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHEuropean XFEL GmbHDeutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYSchool of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of QueenslandDeutsches Elektronen-Synchrotron DESYPhysics Department, University of Wisconsin-MilwaukeeCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYDeutsches Elektronen-Synchrotron DESYInstitute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität HamburgEuropean XFEL GmbHCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala UniversityCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYPaul Scherrer InstitutEuropean XFEL GmbHEuropean XFEL GmbHThe Hamburg Center for Ultrafast Imaging, Universität HamburgCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala UniversityLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala UniversityEuropean XFEL GmbHThe Hamburg Center for Ultrafast Imaging, Universität HamburgAustralian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe Institute for Molecular Sciences, La Trobe UniversityInstitute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität HamburgDiamond Light Source, Research Complex at Harwell, and University of Oxford, Diamond House, Harwell Science and Innovation CampusPhysics Department, University of Wisconsin-MilwaukeeCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYDeutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE)Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of LübeckInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE)European XFEL GmbHCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYPhysics Department, University of Wisconsin-MilwaukeePaul Scherrer InstitutInstitute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of LübeckEuropean XFEL GmbHBiomedical and X-Ray Physics, Department of Applied Physics, AlbaNova University Center, KTH Royal Institute of TechnologyLaboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala UniversityCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYLawrence Livermore National LaboratoryMax Planck Institute for Medical ResearchEuropean XFEL GmbHEuropean XFEL GmbHPhysics Department, Rutgers University NewarkPaul Scherrer InstitutCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHEuropean XFEL GmbHCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYThe Hamburg Center for Ultrafast Imaging, Universität HamburgDeutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYInstitute for Glycomics, Griffith UniversityEuropean XFEL GmbHCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYEuropean XFEL GmbHEuropean XFEL GmbHCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYDepartment of Physics, Arizona State UniversityPaul Scherrer InstitutThe Hamburg Center for Ultrafast Imaging, Universität HamburgEuropean XFEL GmbHThe Hamburg Center for Ultrafast Imaging, Universität HamburgCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYCenter for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESYThe new European X-Ray Free-Electron Laser (EuXFEL) is the first XFEL that generates X-ray pulses with a megahertz inter-pulse spacing. Here the authors demonstrate that high-quality and damage-free protein structures can be obtained with the currently available 1.1 MHz repetition rate pulses using lysozyme as a test case and furthermore present a β-lactamase structure.https://doi.org/10.1038/s41467-018-06156-7 |