Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes

Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes

Abstract Background Abnormal lipid metabolism may contribute to an increase in endoplasmic reticulum (ER) stress, resulting in the pathogenesis of non-alcoholic steatohepatitis. Apolipoprotein A-I (apoA-I) accepts cellular free cholesterol and phospholipids transported by ATP-binding cassette transp...

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Bibliographic Details
Main Authors: Qing Guo, Can Zhang, Yutong Wang
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Lipids in Health and Disease
Subjects:
Apolipoprotein A-I
Endoplasmic reticulum stress
Sterol regulatory element binding protein
Non-alcoholic fatty liver disease
Online Access:http://link.springer.com/article/10.1186/s12944-017-0497-3

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