Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to sustained SAPK activation. <i>Dusp1</i> gene knockout in mi...

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Bibliographic Details
Main Authors: Jose M. Bermúdez-Muñoz, Adelaida M. Celaya, Ángela García-Mato, Daniel Muñoz-Espín, Lourdes Rodríguez-de la Rosa, Manuel Serrano, Isabel Varela-Nieto
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
hearing
N-acetylcysteine
glutathione
antioxidants
reactive oxygen species (ROS)
mitochondria
Online Access:https://www.mdpi.com/2076-3921/10/9/1351

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