Effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: A double-blind randomized cross-over controlled clinical trial
Background: This research was to examine the effects of synbiotic intake on minerals, liver enzymes, and blood pressure in patients with type 2 diabetes (T2D). Methods: This randomized, cross-over clinical trial was performed among 62 diabetic patients. Persons were randomly assigned to intake eithe...
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Wolters Kluwer Medknow Publications
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doaj-748a8014271b4c5c9dd9d928edba3f712020-11-24T22:30:28ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132017-01-0181434310.4103/ijpvm.IJPVM_257_16Effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: A double-blind randomized cross-over controlled clinical trialZatollah AsemiMohammad Hossein AarabiMohammad HajijafariSabihe-Alsadat AlizadehReza RazzaghiMajid MazoochiAhmad EsmaillzadehBackground: This research was to examine the effects of synbiotic intake on minerals, liver enzymes, and blood pressure in patients with type 2 diabetes (T2D). Methods: This randomized, cross-over clinical trial was performed among 62 diabetic patients. Persons were randomly assigned to intake either a synbiotic (n = 62) or a control food (n = 62) for 6 weeks. A 3-week washout period was applied following which persons were crossed over to the alternate intervention arm for an additional 6 weeks. The synbiotic was consisted of Lactobacillus sporogenes (1 × 107 CFU), 0.04 g inulin (HPX) as prebiotic. Persons were asked to consume the synbiotic and control foods 27 g a day. Blood pressure was measured, and blood samples were taken at baseline and after 6-week intervention to assess calcium, magnesium, iron, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and total bilirubin. Results: The consumption of a synbiotic food, compared to the control food, resulted in a significant rise of calcium (0.66 vs. −0.14 mg/dL,P= 0.03) and iron (5.06 vs. −9.98 mg/dL,P= 0.03). The decrease of total bilirubin (0.08 vs. −0.04 mg/dL;P = 0.009) was also seen in the synbiotic group compared with the control group. Conclusions: Overall, synbiotic in T2D patients had beneficial effects on calcium, iron, and total bilirubin concentrations.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2017;volume=8;issue=1;spage=43;epage=43;aulast=Blood pressureliver enzymesserum mineralssynbiotictype 2 diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zatollah Asemi Mohammad Hossein Aarabi Mohammad Hajijafari Sabihe-Alsadat Alizadeh Reza Razzaghi Majid Mazoochi Ahmad Esmaillzadeh |
spellingShingle |
Zatollah Asemi Mohammad Hossein Aarabi Mohammad Hajijafari Sabihe-Alsadat Alizadeh Reza Razzaghi Majid Mazoochi Ahmad Esmaillzadeh Effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: A double-blind randomized cross-over controlled clinical trial International Journal of Preventive Medicine Blood pressure liver enzymes serum minerals synbiotic type 2 diabetes |
author_facet |
Zatollah Asemi Mohammad Hossein Aarabi Mohammad Hajijafari Sabihe-Alsadat Alizadeh Reza Razzaghi Majid Mazoochi Ahmad Esmaillzadeh |
author_sort |
Zatollah Asemi |
title |
Effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: A double-blind randomized cross-over controlled clinical trial |
title_short |
Effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: A double-blind randomized cross-over controlled clinical trial |
title_full |
Effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: A double-blind randomized cross-over controlled clinical trial |
title_fullStr |
Effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: A double-blind randomized cross-over controlled clinical trial |
title_full_unstemmed |
Effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: A double-blind randomized cross-over controlled clinical trial |
title_sort |
effects of synbiotic food consumption on serum minerals, liver enzymes, and blood pressure in patients with type 2 diabetes: a double-blind randomized cross-over controlled clinical trial |
publisher |
Wolters Kluwer Medknow Publications |
series |
International Journal of Preventive Medicine |
issn |
2008-7802 2008-8213 |
publishDate |
2017-01-01 |
description |
Background: This research was to examine the effects of synbiotic intake on minerals, liver enzymes, and blood pressure in patients with type 2 diabetes (T2D). Methods: This randomized, cross-over clinical trial was performed among 62 diabetic patients. Persons were randomly assigned to intake either a synbiotic (n = 62) or a control food (n = 62) for 6 weeks. A 3-week washout period was applied following which persons were crossed over to the alternate intervention arm for an additional 6 weeks. The synbiotic was consisted of Lactobacillus sporogenes (1 × 107 CFU), 0.04 g inulin (HPX) as prebiotic. Persons were asked to consume the synbiotic and control foods 27 g a day. Blood pressure was measured, and blood samples were taken at baseline and after 6-week intervention to assess calcium, magnesium, iron, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and total bilirubin. Results: The consumption of a synbiotic food, compared to the control food, resulted in a significant rise of calcium (0.66 vs. −0.14 mg/dL,P= 0.03) and iron (5.06 vs. −9.98 mg/dL,P= 0.03). The decrease of total bilirubin (0.08 vs. −0.04 mg/dL;P = 0.009) was also seen in the synbiotic group compared with the control group. Conclusions: Overall, synbiotic in T2D patients had beneficial effects on calcium, iron, and total bilirubin concentrations. |
topic |
Blood pressure liver enzymes serum minerals synbiotic type 2 diabetes |
url |
http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2017;volume=8;issue=1;spage=43;epage=43;aulast= |
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