Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer’s pathology
Abstract Objective To examine whether apolipoprotein B (ApoB), apolipoprotein A‐1 (ApoA1), or their ratio (ApoB/A1) were associated with early changes in cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) pathology in elderly adults with subjective cognitive decline (SCD). Methods This...
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doaj-7498dcf9c4904f57a7cbe79fb92b8d602021-05-02T20:02:11ZengWileyAnnals of Clinical and Translational Neurology2328-95032020-10-017101766177810.1002/acn3.51153Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer’s pathologyHao Hu0Lan Tan1Yan‐Lin Bi2Wei Xu3Lin Tan4Xue‐Ning Shen5Xiao‐He Hou6Ya‐Hui Ma7Qiang Dong8Jin‐Tai Yu9Department of Neurology Qingdao Municipal HospitalQingdao University Qingdao ChinaDepartment of Neurology Qingdao Municipal HospitalQingdao University Qingdao ChinaDepartment of Anesthesiology Qingdao Municipal HospitalQingdao University Qingdao ChinaDepartment of Neurology Qingdao Municipal HospitalQingdao University Qingdao ChinaDepartment of Neurology Qingdao Municipal HospitalQingdao University Qingdao ChinaDepartment of Neurology and Institute of Neurology WHO Collaborating Center for Research and Training in NeurosciencesHuashan HospitalShanghai Medical CollegeFudan University Shanghai ChinaDepartment of Neurology Qingdao Municipal HospitalQingdao University Qingdao ChinaDepartment of Neurology Qingdao Municipal HospitalQingdao University Qingdao ChinaDepartment of Neurology and Institute of Neurology WHO Collaborating Center for Research and Training in NeurosciencesHuashan HospitalShanghai Medical CollegeFudan University Shanghai ChinaDepartment of Neurology and Institute of Neurology WHO Collaborating Center for Research and Training in NeurosciencesHuashan HospitalShanghai Medical CollegeFudan University Shanghai ChinaAbstract Objective To examine whether apolipoprotein B (ApoB), apolipoprotein A‐1 (ApoA1), or their ratio (ApoB/A1) were associated with early changes in cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) pathology in elderly adults with subjective cognitive decline (SCD). Methods This study included 507 objective cognitive normal participants from the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) database including 288 cognitive normal participants (CN) and 219 SCD. Multiple linear regression models were used to examine the associations of apolipoproteins with CSF AD biomarkers. Results Compared with control group, SCD participants with significant AD biological characteristics had lower ApoB levels (P = 0.0461). In total participants, lower level of serum ApoB was associated with decreases in CSF Aβ42 (P = 0.0015) and Aβ42/40 (P = 0.0081) as well as increases in CSF p‐tau/Aβ42 (P < 0.0001) and t‐tau/Aβ42 (P = 0.0013), independent of APOEɛ4 status. In further subgroup analysis, these associations were more significant in SCD participants (ApoB × Diagnose: P < 0.05). In addition, lower levels of ApoB were also found associated with increases in p‐tau in the SCD subgroup (P = 0.0263). Furthermore, these protective associations were more significant in the overweight participants (ApoB × weight: P < 0.05). Results showed no association between ApoA1 and CSF biomarkers. Interpretation This study is the first to find protective associations of serum ApoB with CSF AD core biomarkers, especially in SCD individuals. It indicated that ApoB may be a potential biomarker for preclinical AD and may play different roles in different stages of AD.https://doi.org/10.1002/acn3.51153 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hao Hu Lan Tan Yan‐Lin Bi Wei Xu Lin Tan Xue‐Ning Shen Xiao‐He Hou Ya‐Hui Ma Qiang Dong Jin‐Tai Yu |
spellingShingle |
Hao Hu Lan Tan Yan‐Lin Bi Wei Xu Lin Tan Xue‐Ning Shen Xiao‐He Hou Ya‐Hui Ma Qiang Dong Jin‐Tai Yu Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer’s pathology Annals of Clinical and Translational Neurology |
author_facet |
Hao Hu Lan Tan Yan‐Lin Bi Wei Xu Lin Tan Xue‐Ning Shen Xiao‐He Hou Ya‐Hui Ma Qiang Dong Jin‐Tai Yu |
author_sort |
Hao Hu |
title |
Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer’s pathology |
title_short |
Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer’s pathology |
title_full |
Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer’s pathology |
title_fullStr |
Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer’s pathology |
title_full_unstemmed |
Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer’s pathology |
title_sort |
association of serum apolipoprotein b with cerebrospinal fluid biomarkers of alzheimer’s pathology |
publisher |
Wiley |
series |
Annals of Clinical and Translational Neurology |
issn |
2328-9503 |
publishDate |
2020-10-01 |
description |
Abstract Objective To examine whether apolipoprotein B (ApoB), apolipoprotein A‐1 (ApoA1), or their ratio (ApoB/A1) were associated with early changes in cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease (AD) pathology in elderly adults with subjective cognitive decline (SCD). Methods This study included 507 objective cognitive normal participants from the Chinese Alzheimer’s Biomarker and LifestylE (CABLE) database including 288 cognitive normal participants (CN) and 219 SCD. Multiple linear regression models were used to examine the associations of apolipoproteins with CSF AD biomarkers. Results Compared with control group, SCD participants with significant AD biological characteristics had lower ApoB levels (P = 0.0461). In total participants, lower level of serum ApoB was associated with decreases in CSF Aβ42 (P = 0.0015) and Aβ42/40 (P = 0.0081) as well as increases in CSF p‐tau/Aβ42 (P < 0.0001) and t‐tau/Aβ42 (P = 0.0013), independent of APOEɛ4 status. In further subgroup analysis, these associations were more significant in SCD participants (ApoB × Diagnose: P < 0.05). In addition, lower levels of ApoB were also found associated with increases in p‐tau in the SCD subgroup (P = 0.0263). Furthermore, these protective associations were more significant in the overweight participants (ApoB × weight: P < 0.05). Results showed no association between ApoA1 and CSF biomarkers. Interpretation This study is the first to find protective associations of serum ApoB with CSF AD core biomarkers, especially in SCD individuals. It indicated that ApoB may be a potential biomarker for preclinical AD and may play different roles in different stages of AD. |
url |
https://doi.org/10.1002/acn3.51153 |
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