Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells

Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T ce...

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Main Authors:	Kim-Long Truong, Stephan Schlickeiser, Katrin Vogt, David Boës, Katarina Stanko, Christine Appelt, Mathias Streitz, Gerald Grütz, Nadja Stobutzki, Christian Meisel, Christina Iwert, Stefan Tomiuk, Julia K. Polansky, Andreas Pascher, Nina Babel, Ulrik Stervbo, Igor Sauer, Undine Gerlach, Birgit Sawitzki
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10018-1

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spelling	doaj-74a94f8ecf9c440db254d28175cce5072021-05-11T12:24:09ZengNature Publishing GroupNature Communications2041-17232019-05-0110111510.1038/s41467-019-10018-1Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cellsKim-Long Truong0Stephan Schlickeiser1Katrin Vogt2David Boës3Katarina Stanko4Christine Appelt5Mathias Streitz6Gerald Grütz7Nadja Stobutzki8Christian Meisel9Christina Iwert10Stefan Tomiuk11Julia K. Polansky12Andreas Pascher13Nina Babel14Ulrik Stervbo15Igor Sauer16Undine Gerlach17Birgit Sawitzki18Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthMilteny Biotec GmbHBerlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité – Universitätsmedizin BerlinDepartment of Surgery, Charité – Universitätsmedizin BerlinBerlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité – Universitätsmedizin BerlinMedical Clinic I, Marien Hospital Herne, University Clinic of Ruhr-University BochumDepartment of Surgery, Charité – Universitätsmedizin BerlinDepartment of Surgery, Charité – Universitätsmedizin BerlinInstitute of Medical Immunology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of HealthDespite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.https://doi.org/10.1038/s41467-019-10018-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kim-Long Truong Stephan Schlickeiser Katrin Vogt David Boës Katarina Stanko Christine Appelt Mathias Streitz Gerald Grütz Nadja Stobutzki Christian Meisel Christina Iwert Stefan Tomiuk Julia K. Polansky Andreas Pascher Nina Babel Ulrik Stervbo Igor Sauer Undine Gerlach Birgit Sawitzki
spellingShingle	Kim-Long Truong Stephan Schlickeiser Katrin Vogt David Boës Katarina Stanko Christine Appelt Mathias Streitz Gerald Grütz Nadja Stobutzki Christian Meisel Christina Iwert Stefan Tomiuk Julia K. Polansky Andreas Pascher Nina Babel Ulrik Stervbo Igor Sauer Undine Gerlach Birgit Sawitzki Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells Nature Communications
author_facet	Kim-Long Truong Stephan Schlickeiser Katrin Vogt David Boës Katarina Stanko Christine Appelt Mathias Streitz Gerald Grütz Nadja Stobutzki Christian Meisel Christina Iwert Stefan Tomiuk Julia K. Polansky Andreas Pascher Nina Babel Ulrik Stervbo Igor Sauer Undine Gerlach Birgit Sawitzki
author_sort	Kim-Long Truong
title	Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells
title_short	Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells
title_full	Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells
title_fullStr	Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells
title_full_unstemmed	Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells
title_sort	killer-like receptors and gpr56 progressive expression defines cytokine production of human cd4+ memory t cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-05-01
description	Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.
url	https://doi.org/10.1038/s41467-019-10018-1
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Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4+ memory T cells

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