Molecular forms of butyrylcholinesterase and obesity
This study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variable...
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Sociedade Brasileira de Genética
2010-01-01
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doaj-74b10c1d2fc9418b851f0bc2b865563c2020-11-25T03:27:39ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852010-01-01333452454Molecular forms of butyrylcholinesterase and obesityDellyana R. BobergLupe Furtado-AlleRicardo L.R. SouzaEleidi A. Chautard-Freire-MaiaThis study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variables with obesity and SNPs of exons 1 and 4 of the BCHE gene. It was shown that obese and unobese individuals do not differ in the RI of each BChE band, even when classifying the sample into three genotypes of exons 1 and 4 of the BCHE gene (-116GG/539AA, -116GG/539AT, -116GA/539AT). Although the mean BChE activity of each band was significantly higher in obese than in unobese blood donors, the proportions of BChE bands were maintained, even under the metabolic stress associated to obesity, thereby leading to infer that this proportion is somehow regulated, and may therefore be important for BChE functions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300011butyrylcholinesterasebody mass indexobesityBCHE gene SNPs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dellyana R. Boberg Lupe Furtado-Alle Ricardo L.R. Souza Eleidi A. Chautard-Freire-Maia |
spellingShingle |
Dellyana R. Boberg Lupe Furtado-Alle Ricardo L.R. Souza Eleidi A. Chautard-Freire-Maia Molecular forms of butyrylcholinesterase and obesity Genetics and Molecular Biology butyrylcholinesterase body mass index obesity BCHE gene SNPs |
author_facet |
Dellyana R. Boberg Lupe Furtado-Alle Ricardo L.R. Souza Eleidi A. Chautard-Freire-Maia |
author_sort |
Dellyana R. Boberg |
title |
Molecular forms of butyrylcholinesterase and obesity |
title_short |
Molecular forms of butyrylcholinesterase and obesity |
title_full |
Molecular forms of butyrylcholinesterase and obesity |
title_fullStr |
Molecular forms of butyrylcholinesterase and obesity |
title_full_unstemmed |
Molecular forms of butyrylcholinesterase and obesity |
title_sort |
molecular forms of butyrylcholinesterase and obesity |
publisher |
Sociedade Brasileira de Genética |
series |
Genetics and Molecular Biology |
issn |
1415-4757 1678-4685 |
publishDate |
2010-01-01 |
description |
This study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variables with obesity and SNPs of exons 1 and 4 of the BCHE gene. It was shown that obese and unobese individuals do not differ in the RI of each BChE band, even when classifying the sample into three genotypes of exons 1 and 4 of the BCHE gene (-116GG/539AA, -116GG/539AT, -116GA/539AT). Although the mean BChE activity of each band was significantly higher in obese than in unobese blood donors, the proportions of BChE bands were maintained, even under the metabolic stress associated to obesity, thereby leading to infer that this proportion is somehow regulated, and may therefore be important for BChE functions. |
topic |
butyrylcholinesterase body mass index obesity BCHE gene SNPs |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300011 |
work_keys_str_mv |
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1724587805605101568 |