A rare KCNE1 polymorphism, D85N, as a genetic modifier of long QT syndrome

A rare KCNE1 polymorphism, D85N, as a genetic modifier of long QT syndrome

Background: The gene KCNE1 encodes the β-subunit of cardiac voltage-gated K+ channels and causes long QT syndrome (LQTS). LQTS is characterized by the prolongation of QT interval and lethal arrhythmias such as torsade de pointes (TdP). A KCNE1 polymorphism, D85N, has been shown to modify the phenoty...

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Main Authors: Kanae Hasegawa, MD, Seiko Ohno, MD, PhD, Hideki Itoh, MD, PhD, Takeru Makiyama, MD, PhD, Takeshi Aiba, MD, PhD, Yasutaka Nakano, MD, PhD, Wataru Shimizu, MD, PhD, Hiroshi Matsuura, MD, PhD, Naomasa Makita, MD, PhD, Minoru Horie, MD, PhD
Format: Article
Language:English
Published: Wiley 2014-06-01
Series:Journal of Arrhythmia
Subjects:
Long QT syndrome
Single nucleotide polymorphism
Modifier
Online Access:http://www.sciencedirect.com/science/article/pii/S1880427613001348

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