Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem/Progenitor Cell Deregulation Mediated by Serotonin
Depression is a common and debilitating mood disorder that increases in prevalence during pregnancy. Worldwide, 7 to 12% of pregnant women experience depression, in which the associated risk factors include socio-demographic, psychological, and socioeconomic variables. Maternal depression could have...
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Format: | Article |
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Frontiers Media S.A.
2021-08-01
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Series: | Frontiers in Cell and Developmental Biology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.632766/full |
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doaj-74c38359167246ecac77689e4658f4b3 |
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record_format |
Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Natalia Sánchez Jesús Juárez-Balarezo Marcia Olhaberry Marcia Olhaberry Humberto González-Oneto Antonia Muzard Antonia Muzard María Jesús Mardonez María Jesús Mardonez Pamela Franco Pamela Franco Felipe Barrera Marcia Gaete |
spellingShingle |
Natalia Sánchez Jesús Juárez-Balarezo Marcia Olhaberry Marcia Olhaberry Humberto González-Oneto Antonia Muzard Antonia Muzard María Jesús Mardonez María Jesús Mardonez Pamela Franco Pamela Franco Felipe Barrera Marcia Gaete Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem/Progenitor Cell Deregulation Mediated by Serotonin Frontiers in Cell and Developmental Biology craniofacial defects antidepressant depression pregnancy stem cells |
author_facet |
Natalia Sánchez Jesús Juárez-Balarezo Marcia Olhaberry Marcia Olhaberry Humberto González-Oneto Antonia Muzard Antonia Muzard María Jesús Mardonez María Jesús Mardonez Pamela Franco Pamela Franco Felipe Barrera Marcia Gaete |
author_sort |
Natalia Sánchez |
title |
Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem/Progenitor Cell Deregulation Mediated by Serotonin |
title_short |
Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem/Progenitor Cell Deregulation Mediated by Serotonin |
title_full |
Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem/Progenitor Cell Deregulation Mediated by Serotonin |
title_fullStr |
Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem/Progenitor Cell Deregulation Mediated by Serotonin |
title_full_unstemmed |
Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem/Progenitor Cell Deregulation Mediated by Serotonin |
title_sort |
depression and antidepressants during pregnancy: craniofacial defects due to stem/progenitor cell deregulation mediated by serotonin |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-08-01 |
description |
Depression is a common and debilitating mood disorder that increases in prevalence during pregnancy. Worldwide, 7 to 12% of pregnant women experience depression, in which the associated risk factors include socio-demographic, psychological, and socioeconomic variables. Maternal depression could have psychological, anatomical, and physiological consequences in the newborn. Depression has been related to a downregulation in serotonin levels in the brain. Accordingly, the most commonly prescribed pharmacotherapy is based on selective serotonin reuptake inhibitors (SSRIs), which increase local serotonin concentration. Even though the use of SSRIs has few adverse effects compared with other antidepressants, altering serotonin levels has been associated with the advent of anatomical and physiological changes in utero, leading to defects in craniofacial development, including craniosynostosis, cleft palate, and dental defects. Migration and proliferation of neural crest cells, which contribute to the formation of bone, cartilage, palate, teeth, and salivary glands in the craniofacial region, are regulated by serotonin. Specifically, craniofacial progenitor cells are affected by serotonin levels, producing a misbalance between their proliferation and differentiation. Thus, it is possible to hypothesize that craniofacial development will be affected by the changes in serotonin levels, happening during maternal depression or after the use of SSRIs, which cross the placental barrier, increasing the risk of craniofacial defects. In this review, we provide a synthesis of the current research on depression and the use of SSRI during pregnancy, and how this could be related to craniofacial defects using an interdisciplinary perspective integrating psychological, clinical, and developmental biology perspectives. We discuss the mechanisms by which serotonin could influence craniofacial development and stem/progenitor cells, proposing some transcription factors as mediators of serotonin signaling, and craniofacial stem/progenitor cell biology. We finally highlight the importance of non-pharmacological therapies for depression on fertile and pregnant women, and provide an individual analysis of the risk–benefit balance for the use of antidepressants during pregnancy |
topic |
craniofacial defects antidepressant depression pregnancy stem cells |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.632766/full |
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doaj-74c38359167246ecac77689e4658f4b32021-08-12T10:09:32ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-08-01910.3389/fcell.2021.632766632766Depression and Antidepressants During Pregnancy: Craniofacial Defects Due to Stem/Progenitor Cell Deregulation Mediated by SerotoninNatalia Sánchez0Jesús Juárez-Balarezo1Marcia Olhaberry2Marcia Olhaberry3Humberto González-Oneto4Antonia Muzard5Antonia Muzard6María Jesús Mardonez7María Jesús Mardonez8Pamela Franco9Pamela Franco10Felipe Barrera11Marcia Gaete12Department of Anatomy, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Anatomy, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Psychology, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute for Research in Depression and Personality (MIDAP), Santiago, ChileSchool of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Psychology, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute for Research in Depression and Personality (MIDAP), Santiago, ChileDepartment of Psychology, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute for Research in Depression and Personality (MIDAP), Santiago, ChileDepartment of Psychology, Pontificia Universidad Católica de Chile, Santiago, ChileMillennium Institute for Research in Depression and Personality (MIDAP), Santiago, ChileSchool of Dentistry, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileDepartment of Anatomy, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileDepression is a common and debilitating mood disorder that increases in prevalence during pregnancy. Worldwide, 7 to 12% of pregnant women experience depression, in which the associated risk factors include socio-demographic, psychological, and socioeconomic variables. Maternal depression could have psychological, anatomical, and physiological consequences in the newborn. Depression has been related to a downregulation in serotonin levels in the brain. Accordingly, the most commonly prescribed pharmacotherapy is based on selective serotonin reuptake inhibitors (SSRIs), which increase local serotonin concentration. Even though the use of SSRIs has few adverse effects compared with other antidepressants, altering serotonin levels has been associated with the advent of anatomical and physiological changes in utero, leading to defects in craniofacial development, including craniosynostosis, cleft palate, and dental defects. Migration and proliferation of neural crest cells, which contribute to the formation of bone, cartilage, palate, teeth, and salivary glands in the craniofacial region, are regulated by serotonin. Specifically, craniofacial progenitor cells are affected by serotonin levels, producing a misbalance between their proliferation and differentiation. Thus, it is possible to hypothesize that craniofacial development will be affected by the changes in serotonin levels, happening during maternal depression or after the use of SSRIs, which cross the placental barrier, increasing the risk of craniofacial defects. In this review, we provide a synthesis of the current research on depression and the use of SSRI during pregnancy, and how this could be related to craniofacial defects using an interdisciplinary perspective integrating psychological, clinical, and developmental biology perspectives. We discuss the mechanisms by which serotonin could influence craniofacial development and stem/progenitor cells, proposing some transcription factors as mediators of serotonin signaling, and craniofacial stem/progenitor cell biology. We finally highlight the importance of non-pharmacological therapies for depression on fertile and pregnant women, and provide an individual analysis of the risk–benefit balance for the use of antidepressants during pregnancyhttps://www.frontiersin.org/articles/10.3389/fcell.2021.632766/fullcraniofacial defectsantidepressantdepressionpregnancystem cells |