Value of Gd-EOB-DTPA-enhanced MRI in assessing liver function

• Main Author: WANG Lili
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2015-05-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: liver function tests; magnetic resonance imaging; Gd-EOB-DTPA; contrast media
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=6513&ClassID=4159435
• ISSN: 1001-5256; 1001-5256

ObjectiveTo explore the value of magnetic resonance imaging (MRI) specifically enhanced with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in assessing the liver function in general population. MethodsUpper abdominal MRI images and Gd-EOB-DTPA-enhanced images, as well as some clinical information, were collected from 41 cases meeting the inclusion and exclusion criteria. Taking the spleen as the control organ, liver-spleen signal intensity contrast (SIliver/spleen) and relative liver enhancement (RLE) were calculated at 10 min and 20 min after injecting Gd-EOB-DTPA. Differences were evaluated using the independent-samples t-test or Mann-Whitney U test. Corrections were analyzed via Spearman’s rank correlation. ResultsBoth SIliver/spleen at 10 min and 20 min after injection of contrast agent were correlated with Child classification (P＜0.05). SIliver/spleen at 20 min had a greater correlation coefficient (r=-0.526) than that at 10 min. The SIliver/spleen with plain scan had no significant correlation with Child classification (P＞0.05). RLE at 20 min, but not at 10 min, was correlated with Child classification (r=-0.362, P=0049). Between the cirrhotic and non-cirrhotic groups, SIliver/spleen showed no significant difference (P＞0.05). However, SIliver/spleen at 10 min and 20 min, as well as RLE20 min, showed significant differences between the cirrhotic and non-cirrhotic groups (P＜0.05). SIliver/spleen at 20 min also exhibited a significant difference between the elevated and normal ALT and TBil groups (both P＜0.05). ConclusionGd-EOB-DTPA-enhanced MRI can monitor liver function changes, and SIliver/spleen at 20 min may have an important value in assessing the liver function in general population.