A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 2; referees: 2 approved]
The increased application of high-throughput approaches in translational research has expanded the number of publicly available data repositories. Gathering additional valuable information contained in the datasets represents a crucial opportunity in the biomedical field. To facilitate and stimulate...
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F1000 Research Ltd
2018-02-01
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Online Access: | https://f1000research.com/articles/6-296/v2 |
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doaj-74d4227ab9c94ab294e504f4a7d3166b |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jessica Roelands Julie Decock Sabri Boughorbel Darawan Rinchai Cristina Maccalli Michele Ceccarelli Michael Black Cris Print Jeff Chou Scott Presnell Charlie Quinn Puthen Jithesh Najeeb Syed Salha B.J. Al Bader Shahinaz Bedri Ena Wang Francesco M. Marincola Damien Chaussabel Peter Kuppen Lance D. Miller Davide Bedognetti Wouter Hendrickx |
spellingShingle |
Jessica Roelands Julie Decock Sabri Boughorbel Darawan Rinchai Cristina Maccalli Michele Ceccarelli Michael Black Cris Print Jeff Chou Scott Presnell Charlie Quinn Puthen Jithesh Najeeb Syed Salha B.J. Al Bader Shahinaz Bedri Ena Wang Francesco M. Marincola Damien Chaussabel Peter Kuppen Lance D. Miller Davide Bedognetti Wouter Hendrickx A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 2; referees: 2 approved] F1000Research Bioinformatics Breast Diseases: Benign & Malignant Data Sharing Genomics |
author_facet |
Jessica Roelands Julie Decock Sabri Boughorbel Darawan Rinchai Cristina Maccalli Michele Ceccarelli Michael Black Cris Print Jeff Chou Scott Presnell Charlie Quinn Puthen Jithesh Najeeb Syed Salha B.J. Al Bader Shahinaz Bedri Ena Wang Francesco M. Marincola Damien Chaussabel Peter Kuppen Lance D. Miller Davide Bedognetti Wouter Hendrickx |
author_sort |
Jessica Roelands |
title |
A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 2; referees: 2 approved] |
title_short |
A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 2; referees: 2 approved] |
title_full |
A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 2; referees: 2 approved] |
title_fullStr |
A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 2; referees: 2 approved] |
title_full_unstemmed |
A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 2; referees: 2 approved] |
title_sort |
collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 2; referees: 2 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2018-02-01 |
description |
The increased application of high-throughput approaches in translational research has expanded the number of publicly available data repositories. Gathering additional valuable information contained in the datasets represents a crucial opportunity in the biomedical field. To facilitate and stimulate utilization of these datasets, we have recently developed an interactive data browsing and visualization web application, the Gene Expression Browser (GXB). In this note, we describe a curated compendium of 13 public datasets on human breast cancer, representing a total of 2142 transcriptome profiles. We classified the samples according to different immune based classification systems and integrated this information into the datasets. Annotated and harmonized datasets were uploaded to GXB. Study samples were categorized in different groups based on their immunologic tumor response profiles, intrinsic molecular subtypes and multiple clinical parameters. Ranked gene lists were generated based on relevant group comparisons. In this data note, we demonstrate the utility of GXB to evaluate the expression of a gene of interest, find differential gene expression between groups and investigate potential associations between variables with a specific focus on immunologic classification in breast cancer. This interactive resource is publicly available online at: http://breastcancer.gxbsidra.org/dm3/geneBrowser/list. |
topic |
Bioinformatics Breast Diseases: Benign & Malignant Data Sharing Genomics |
url |
https://f1000research.com/articles/6-296/v2 |
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doaj-74d4227ab9c94ab294e504f4a7d3166b2020-11-25T04:03:54ZengF1000 Research LtdF1000Research2046-14022018-02-01610.12688/f1000research.10960.215014A collection of annotated and harmonized human breast cancer transcriptome datasets, including immunologic classification [version 2; referees: 2 approved]Jessica Roelands0Julie Decock1Sabri Boughorbel2Darawan Rinchai3Cristina Maccalli4Michele Ceccarelli5Michael Black6Cris Print7Jeff Chou8Scott Presnell9Charlie Quinn10Puthen Jithesh11Najeeb Syed12Salha B.J. Al Bader13Shahinaz Bedri14Ena Wang15Francesco M. Marincola16Damien Chaussabel17Peter Kuppen18Lance D. Miller19Davide Bedognetti20Wouter Hendrickx21Tumor Biology, Immunology and Therapy section, Sidra Medical and Research Center, Doha, QatarQatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, QatarSystems Biology Department, Sidra Medical and Research Center, Doha, QatarTumor Biology, Immunology and Therapy section, Sidra Medical and Research Center, Doha, QatarTumor Biology, Immunology and Therapy section, Sidra Medical and Research Center, Doha, QatarQatar Computing Research Institute, Doha, QatarDepartment of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, 9054, New ZealandDepartment of Molecular Medicine and Pathology and Maurice Wilkins Institute, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New ZealandDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USABenaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USABenaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USATranslational Bioinformatics, Division of Biomedical Informatics Research, Sidra Medical and Research Center, Doha, QatarTechnical Bioinformatics team, Biomedical Informatics Division, Sidra Medical and Research Center, Doha, QatarNational Center for Cancer Care and Research (NCCCR), Hamad General Hospital, Doha, QatarWeill Cornell Medicine - Qatar, Doha, QatarDivision of Translational Medicine, Research Branch, Sidra Medical and Research Center, Doha, QatarOffice of the Chief Research Officer (CRO), Research Branch, Sidra Medical and Research Center, Doha, QatarSystems Biology Department, Sidra Medical and Research Center, Doha, QatarDepartment of Surgery, Leiden University Medical Center, Leiden, 2333 ZA, NetherlandsDepartment of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USATumor Biology, Immunology and Therapy section, Sidra Medical and Research Center, Doha, QatarTumor Biology, Immunology and Therapy section, Sidra Medical and Research Center, Doha, QatarThe increased application of high-throughput approaches in translational research has expanded the number of publicly available data repositories. Gathering additional valuable information contained in the datasets represents a crucial opportunity in the biomedical field. To facilitate and stimulate utilization of these datasets, we have recently developed an interactive data browsing and visualization web application, the Gene Expression Browser (GXB). In this note, we describe a curated compendium of 13 public datasets on human breast cancer, representing a total of 2142 transcriptome profiles. We classified the samples according to different immune based classification systems and integrated this information into the datasets. Annotated and harmonized datasets were uploaded to GXB. Study samples were categorized in different groups based on their immunologic tumor response profiles, intrinsic molecular subtypes and multiple clinical parameters. Ranked gene lists were generated based on relevant group comparisons. In this data note, we demonstrate the utility of GXB to evaluate the expression of a gene of interest, find differential gene expression between groups and investigate potential associations between variables with a specific focus on immunologic classification in breast cancer. This interactive resource is publicly available online at: http://breastcancer.gxbsidra.org/dm3/geneBrowser/list.https://f1000research.com/articles/6-296/v2BioinformaticsBreast Diseases: Benign & MalignantData SharingGenomics |