Modulation of Human Adipose Stem Cells’ Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro

Modulation of Human Adipose Stem Cells’ Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro

We report on a potential strategy involving the exogenous neurotrophic factors (NTF) for enhancing the neurotrophic capacity of human adipose stem cells (ASC) in vitro. For this, ASC were stimulated for three days using NTF, i.e., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF),...

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Bibliographic Details
Main Authors: Katharina M. Prautsch, Alexander Schmidt, Viola Paradiso, Dirk J. Schaefer, Raphael Guzman, Daniel F. Kalbermatten, Srinivas Madduri
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
human adipose stem cells
neurotrophic factors
peripheral nerve injuries
axonal regeneration
Schwann cells
ex vivo stimulation
Online Access:https://www.mdpi.com/2073-4409/9/9/1939

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