TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis
Previous large-scale genetic studies identified single nucleotide polymorphisms (SNPs) of the TM6SF2 and MBOAT7 genes as risk factors for alcoholic liver cirrhosis and non-alcoholic fatty liver disease. In this study, we tried to evaluate the association between TM6SF2 variant rs58542926 and MBOAT7...
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doaj-74d982b8d13b4e47bf0e895edc521f372020-11-24T22:09:27ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-03-01206127710.3390/ijms20061277ijms20061277TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and CirrhosisViktorija Basyte-Bacevice0Jurgita Skieceviciene1Irena Valantiene2Jolanta Sumskiene3Vitalija Petrenkiene4Jurate Kondrackiene5Dalius Petrauskas6Frank Lammert7Juozas Kupcinskas8Department of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaInstitute for Digestive Research, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaDepartment of Medicine II, Saarland University Medical Center, Saarland University, 66421 Homburg, GermanyDepartment of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, LithuaniaPrevious large-scale genetic studies identified single nucleotide polymorphisms (SNPs) of the TM6SF2 and MBOAT7 genes as risk factors for alcoholic liver cirrhosis and non-alcoholic fatty liver disease. In this study, we tried to evaluate the association between TM6SF2 variant rs58542926 and MBOAT7 variant rs641738 and the risk of hepatic fibrosis or liver cirrhosis of different etiology. In parallel, we also aimed to evaluate whether these two SNPs modify the effects of the PNPLA3 rs738409 risk variant for the development of hepatic fibrosis and liver cirrhosis. The study was conducted at the Department of Gastroenterology, Lithuanian University of Health Sciences Hospital, and included 334 patients with liver cirrhosis, 128 patients with liver fibrosis, and 550 controls. SNPs were genotyped by quantitative PCR, using TaqMan allelic discrimination assays. Overall, TM6SF2 rs58542926 as well as MBOAT7 rs641738 were not linked to hepatic fibrosis, alcohol or hepatitis C virus induced liver cirrhosis in an Eastern European population. These genetic variations also did not mediate the effect of PNPLA3 rs738409 SNP for liver developing liver fibrosis or liver cirrhosis.http://www.mdpi.com/1422-0067/20/6/1277hepatic fibrosisliver cirrhosisMBOAT7TM6SF2PNPLA3gene polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Viktorija Basyte-Bacevice Jurgita Skieceviciene Irena Valantiene Jolanta Sumskiene Vitalija Petrenkiene Jurate Kondrackiene Dalius Petrauskas Frank Lammert Juozas Kupcinskas |
spellingShingle |
Viktorija Basyte-Bacevice Jurgita Skieceviciene Irena Valantiene Jolanta Sumskiene Vitalija Petrenkiene Jurate Kondrackiene Dalius Petrauskas Frank Lammert Juozas Kupcinskas TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis International Journal of Molecular Sciences hepatic fibrosis liver cirrhosis MBOAT7 TM6SF2 PNPLA3 gene polymorphism |
author_facet |
Viktorija Basyte-Bacevice Jurgita Skieceviciene Irena Valantiene Jolanta Sumskiene Vitalija Petrenkiene Jurate Kondrackiene Dalius Petrauskas Frank Lammert Juozas Kupcinskas |
author_sort |
Viktorija Basyte-Bacevice |
title |
TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis |
title_short |
TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis |
title_full |
TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis |
title_fullStr |
TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis |
title_full_unstemmed |
TM6SF2 and MBOAT7 Gene Variants in Liver Fibrosis and Cirrhosis |
title_sort |
tm6sf2 and mboat7 gene variants in liver fibrosis and cirrhosis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-03-01 |
description |
Previous large-scale genetic studies identified single nucleotide polymorphisms (SNPs) of the TM6SF2 and MBOAT7 genes as risk factors for alcoholic liver cirrhosis and non-alcoholic fatty liver disease. In this study, we tried to evaluate the association between TM6SF2 variant rs58542926 and MBOAT7 variant rs641738 and the risk of hepatic fibrosis or liver cirrhosis of different etiology. In parallel, we also aimed to evaluate whether these two SNPs modify the effects of the PNPLA3 rs738409 risk variant for the development of hepatic fibrosis and liver cirrhosis. The study was conducted at the Department of Gastroenterology, Lithuanian University of Health Sciences Hospital, and included 334 patients with liver cirrhosis, 128 patients with liver fibrosis, and 550 controls. SNPs were genotyped by quantitative PCR, using TaqMan allelic discrimination assays. Overall, TM6SF2 rs58542926 as well as MBOAT7 rs641738 were not linked to hepatic fibrosis, alcohol or hepatitis C virus induced liver cirrhosis in an Eastern European population. These genetic variations also did not mediate the effect of PNPLA3 rs738409 SNP for liver developing liver fibrosis or liver cirrhosis. |
topic |
hepatic fibrosis liver cirrhosis MBOAT7 TM6SF2 PNPLA3 gene polymorphism |
url |
http://www.mdpi.com/1422-0067/20/6/1277 |
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