Hyperthermia Efficiency of Magnetic Nanoparticles in Dense Aggregates of Cerium Oxide/Iron Oxide Nanoparticles

• Main Authors: Cindy Yadel, Aude Michel, Sandra Casale, Jerome Fresnais
• Format: Article
• Language: English
• Published: MDPI AG 2018-07-01
• Series: Applied Sciences
• Subjects: magnetic nanoparticle; hyperthermia; aggregation; dipolar interactions
• Online Access: http://www.mdpi.com/2076-3417/8/8/1241

Iron oxide nanoparticles are intended to be used in bio-applications for drug delivery associated with hyperthermia. However, their interactions with complex media often induces aggregation, and thus a detrimental decrease of their heating efficiency. We have investigated the role of iron oxide nanoparticles dispersion into dense aggregates composed with magnetic/non-magnetic nanoparticles and showed that, when iron oxide nanoparticles were well-distributed into the aggregates, the specific absorption rate reached 79% of the value measured for the well-dispersed case. This study should have a strong impact on the applications of magnetic nanoparticles into nanostructured materials for therapy or catalysis applications.