Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice
Histone deacetylases (HDACs) are important regulators of epigenetic gene modification that are involved in the transcriptional control of metabolism. In particular class IIa HDACs have been shown to affect hepatic gluconeogenesis and previous approaches revealed that their inhibition reduces blood g...
Main Authors: | Nicole Ziegler, Suryaprakash Raichur, Bodo Brunner, Ulrike Hemmann, Manuela Stolte, Uwe Schwahn, Hans-Peter Prochnow, Christiane Metz-Weidmann, Norbert Tennagels, Daniel Margerie, Paulus Wohlfart, Maximilian Bielohuby |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-08-01
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Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00598/full |
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