Rai1 frees mice from the repression of active wake behaviors by light
Besides its role in vision, light impacts physiology and behavior through circadian and direct (aka ‘masking’) mechanisms. In Smith-Magenis syndrome (SMS), the dysregulation of both sleep-wake behavior and melatonin production strongly suggests impaired non-visual light perception. We discovered tha...
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doaj-75142bb692264fe080ddfc08101caa662021-05-05T13:30:23ZengeLife Sciences Publications LtdeLife2050-084X2017-05-01610.7554/eLife.23292Rai1 frees mice from the repression of active wake behaviors by lightShanaz Diessler0Corinne Kostic1Yvan Arsenijevic2Aki Kawasaki3Paul Franken4https://orcid.org/0000-0002-2500-2921Center for Integrative Genomics, University of Lausanne, Lausanne, SwitzerlandJules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Lausanne, SwitzerlandJules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Lausanne, SwitzerlandCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Lausanne, SwitzerlandCenter for Integrative Genomics, University of Lausanne, Lausanne, SwitzerlandBesides its role in vision, light impacts physiology and behavior through circadian and direct (aka ‘masking’) mechanisms. In Smith-Magenis syndrome (SMS), the dysregulation of both sleep-wake behavior and melatonin production strongly suggests impaired non-visual light perception. We discovered that mice haploinsufficient for the SMS causal gene, Retinoic acid induced-1 (Rai1), were hypersensitive to light such that light eliminated alert and active-wake behaviors, while leaving time-spent-awake unaffected. Moreover, variables pertaining to circadian rhythm entrainment were activated more strongly by light. At the input level, the activation of rod/cone and suprachiasmatic nuclei (SCN) by light was paradoxically greatly reduced, while the downstream activation of the ventral-subparaventricular zone (vSPVZ) was increased. The vSPVZ integrates retinal and SCN input and, when activated, suppresses locomotor activity, consistent with the behavioral hypersensitivity to light we observed. Our results implicate Rai1 as a novel and central player in processing non-visual light information, from input to behavioral output.https://elifesciences.org/articles/23292lightcircadian rhythmsleepsmith-magenis syndromesupra-chiasmatic nucleiventral-subparaventricular zone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shanaz Diessler Corinne Kostic Yvan Arsenijevic Aki Kawasaki Paul Franken |
spellingShingle |
Shanaz Diessler Corinne Kostic Yvan Arsenijevic Aki Kawasaki Paul Franken Rai1 frees mice from the repression of active wake behaviors by light eLife light circadian rhythm sleep smith-magenis syndrome supra-chiasmatic nuclei ventral-subparaventricular zone |
author_facet |
Shanaz Diessler Corinne Kostic Yvan Arsenijevic Aki Kawasaki Paul Franken |
author_sort |
Shanaz Diessler |
title |
Rai1 frees mice from the repression of active wake behaviors by light |
title_short |
Rai1 frees mice from the repression of active wake behaviors by light |
title_full |
Rai1 frees mice from the repression of active wake behaviors by light |
title_fullStr |
Rai1 frees mice from the repression of active wake behaviors by light |
title_full_unstemmed |
Rai1 frees mice from the repression of active wake behaviors by light |
title_sort |
rai1 frees mice from the repression of active wake behaviors by light |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2017-05-01 |
description |
Besides its role in vision, light impacts physiology and behavior through circadian and direct (aka ‘masking’) mechanisms. In Smith-Magenis syndrome (SMS), the dysregulation of both sleep-wake behavior and melatonin production strongly suggests impaired non-visual light perception. We discovered that mice haploinsufficient for the SMS causal gene, Retinoic acid induced-1 (Rai1), were hypersensitive to light such that light eliminated alert and active-wake behaviors, while leaving time-spent-awake unaffected. Moreover, variables pertaining to circadian rhythm entrainment were activated more strongly by light. At the input level, the activation of rod/cone and suprachiasmatic nuclei (SCN) by light was paradoxically greatly reduced, while the downstream activation of the ventral-subparaventricular zone (vSPVZ) was increased. The vSPVZ integrates retinal and SCN input and, when activated, suppresses locomotor activity, consistent with the behavioral hypersensitivity to light we observed. Our results implicate Rai1 as a novel and central player in processing non-visual light information, from input to behavioral output. |
topic |
light circadian rhythm sleep smith-magenis syndrome supra-chiasmatic nuclei ventral-subparaventricular zone |
url |
https://elifesciences.org/articles/23292 |
work_keys_str_mv |
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