Use of Bone Marrow derived Stem Cells in patients with Cardiovascular Disorders
Patients with end stage heart failure have very few treatment options. The long waiting times for transplant and the complications associated with immunosuppression has led to the search for alternatives. Subsequent to the isolation and characterization of stem cells, tremendous advances have been m...
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doaj-7528dc125e1043c1bd5342e1f9169b7f2020-11-25T02:16:42ZengGN Corporation LimitedJournal of Stem Cells and Regenerative Medicine0973-71542007-01-01312829Use of Bone Marrow derived Stem Cells in patients with Cardiovascular DisordersAbraham SNaveen ATKirtivasan VPrasad GNKarthik VaidyanathanRajesh VMadhusankar NCherian KMPatients with end stage heart failure have very few treatment options. The long waiting times for transplant and the complications associated with immunosuppression has led to the search for alternatives. Subsequent to the isolation and characterization of stem cells, tremendous advances have been made and the safety and feasibility of autologous bone marrow derived stem cells has been proven in preclinical studies. Clinical studies have also shown mobilized cells repair the infracted heart, improving function and survival. We have started a clinical study to evaluate the efficacy of bone marrow derived stem cells. Bone-marrow was aspirated from the right iliac crest and the stem cells were isolated by density gradient method and suspended according to the mode of delivery.From Jan 2007 till date 10 patients (8 adults, 2 children, age) with end stage cardiovascular disorder of varied etiology (Ischemic left ventricular dysfunction - 6 patients, Primary pulmonary hypertension - 2 patients, Dilated cardiomyopathy -1 patient, Biventricular non-compaction -1 patient) underwent stem cell therapy. All patients were evaluated and cardiac function was measured by using echocardiography and thallium scintigraphy. There were no procedure related complications. These patients are being regularly followed-up and one patient who has completed 6-month follow-up has shown improvement in perfusion as well as increase in ejection fraction of 10%. Stem cell therapy in patients with end-stage cardiovascular disorder might be a promising tool by means of angiogenesis and other paracrine mechanisms.http://www.pubstemcell.com/monthly/003010700010.htmProceedings of Annual Symposium on Regenerative Medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abraham S Naveen AT Kirtivasan V Prasad GN Karthik Vaidyanathan Rajesh V Madhusankar N Cherian KM |
spellingShingle |
Abraham S Naveen AT Kirtivasan V Prasad GN Karthik Vaidyanathan Rajesh V Madhusankar N Cherian KM Use of Bone Marrow derived Stem Cells in patients with Cardiovascular Disorders Journal of Stem Cells and Regenerative Medicine Proceedings of Annual Symposium on Regenerative Medicine |
author_facet |
Abraham S Naveen AT Kirtivasan V Prasad GN Karthik Vaidyanathan Rajesh V Madhusankar N Cherian KM |
author_sort |
Abraham S |
title |
Use of Bone Marrow derived Stem Cells in patients with Cardiovascular Disorders |
title_short |
Use of Bone Marrow derived Stem Cells in patients with Cardiovascular Disorders |
title_full |
Use of Bone Marrow derived Stem Cells in patients with Cardiovascular Disorders |
title_fullStr |
Use of Bone Marrow derived Stem Cells in patients with Cardiovascular Disorders |
title_full_unstemmed |
Use of Bone Marrow derived Stem Cells in patients with Cardiovascular Disorders |
title_sort |
use of bone marrow derived stem cells in patients with cardiovascular disorders |
publisher |
GN Corporation Limited |
series |
Journal of Stem Cells and Regenerative Medicine |
issn |
0973-7154 |
publishDate |
2007-01-01 |
description |
Patients with end stage heart failure have very few treatment options. The long waiting times for transplant and the complications associated with immunosuppression has led to the search for alternatives. Subsequent to the isolation and characterization of stem cells, tremendous advances have been made and the safety and feasibility of autologous bone marrow derived stem cells has been proven in preclinical studies. Clinical studies have also shown mobilized cells repair the infracted heart, improving function and survival. We have started a clinical study to evaluate the efficacy of bone marrow derived stem cells. Bone-marrow was aspirated from the right iliac crest and the stem cells were isolated by density gradient method and suspended according to the mode of delivery.From Jan 2007 till date 10 patients (8 adults, 2 children, age) with end stage cardiovascular disorder of varied etiology (Ischemic left ventricular dysfunction - 6 patients, Primary pulmonary hypertension - 2 patients, Dilated cardiomyopathy -1 patient, Biventricular non-compaction -1 patient) underwent stem cell therapy. All patients were evaluated and cardiac function was measured by using echocardiography and thallium scintigraphy. There were no procedure related complications. These patients are being regularly followed-up and one patient who has completed 6-month follow-up has shown improvement in perfusion as well as increase in ejection fraction of 10%. Stem cell therapy in patients with end-stage cardiovascular disorder might be a promising tool by means of angiogenesis and other paracrine mechanisms. |
topic |
Proceedings of Annual Symposium on Regenerative Medicine |
url |
http://www.pubstemcell.com/monthly/003010700010.htm |
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