Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease

Conditional Myh9 and Myh10 inactivation in adult mouse renal epithelium results in progressive kidney disease

Actin-associated nonmuscle myosin II (NM2) motor proteins play critical roles in a myriad of cellular functions, including endocytosis and organelle transport pathways. Cell type–specific expression and unique subcellular localization of the NM2 proteins, encoded by the Myh9 and Myh10 genes, in the...

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Bibliographic Details
Main Authors: Karla L. Otterpohl, Brook W. Busselman, Ishara Ratnayake, Ryan G. Hart, Kimberly R. Hart, Claire M. Evans, Carrie L. Phillips, Jordan R. Beach, Phil Ahrenkiel, Bruce A. Molitoris, Kameswaran Surendran, Indra Chandrasekar
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-11-01
Series:JCI Insight
Subjects:
Cell biology
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.138530

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