Arginine as a Synergistic Virucidal Agent
Development of effective and environmentally friendly disinfectants, or virucidal agents, should help prevent the spread of infectious diseases through human contact with contaminated surfaces. These agents may also be used, if non-toxic to cells and tissues, as chemotherapeutic agents against infec...
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Online Access: | http://www.mdpi.com/1420-3049/15/3/1408/ |
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doaj-753bb3b159f74d9ab005e771df0acdf52020-11-25T00:04:21ZengMDPI AGMolecules1420-30492010-03-011531408142410.3390/molecules15031408Arginine as a Synergistic Virucidal AgentA. Hajime KoyamaSatoshi OhtakeTsutomu ArakawaDevelopment of effective and environmentally friendly disinfectants, or virucidal agents, should help prevent the spread of infectious diseases through human contact with contaminated surfaces. These agents may also be used, if non-toxic to cells and tissues, as chemotherapeutic agents against infectious diseases. We have shown that arginine has a synergistic effect with a variety of virucidal conditions, namely acidic pH and high temperature, on virus inactivation. All of these treatments are effective, however, at the expense of toxicity. The ability of arginine to lower the effective threshold of these parameters may reduce the occurrence of potential toxic side effects. While it is clear that arginine can be safely used, the mechanism of its virus inactivation has not yet been elucidated. Here we examine the damages that viruses suffer from various physical and chemical stresses and their relations to virus inactivation and aggregation. Based on the relationship between the stress-induced structural damages and the infectivity of a virus, we will propose several plausible mechanisms describing the effects of arginine on virus inactivation using the current knowledge of aqueous arginine solution properties. http://www.mdpi.com/1420-3049/15/3/1408/virus inactivationargininevirus aggregationinfectivitydisinfectant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A. Hajime Koyama Satoshi Ohtake Tsutomu Arakawa |
spellingShingle |
A. Hajime Koyama Satoshi Ohtake Tsutomu Arakawa Arginine as a Synergistic Virucidal Agent Molecules virus inactivation arginine virus aggregation infectivity disinfectant |
author_facet |
A. Hajime Koyama Satoshi Ohtake Tsutomu Arakawa |
author_sort |
A. Hajime Koyama |
title |
Arginine as a Synergistic Virucidal Agent |
title_short |
Arginine as a Synergistic Virucidal Agent |
title_full |
Arginine as a Synergistic Virucidal Agent |
title_fullStr |
Arginine as a Synergistic Virucidal Agent |
title_full_unstemmed |
Arginine as a Synergistic Virucidal Agent |
title_sort |
arginine as a synergistic virucidal agent |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2010-03-01 |
description |
Development of effective and environmentally friendly disinfectants, or virucidal agents, should help prevent the spread of infectious diseases through human contact with contaminated surfaces. These agents may also be used, if non-toxic to cells and tissues, as chemotherapeutic agents against infectious diseases. We have shown that arginine has a synergistic effect with a variety of virucidal conditions, namely acidic pH and high temperature, on virus inactivation. All of these treatments are effective, however, at the expense of toxicity. The ability of arginine to lower the effective threshold of these parameters may reduce the occurrence of potential toxic side effects. While it is clear that arginine can be safely used, the mechanism of its virus inactivation has not yet been elucidated. Here we examine the damages that viruses suffer from various physical and chemical stresses and their relations to virus inactivation and aggregation. Based on the relationship between the stress-induced structural damages and the infectivity of a virus, we will propose several plausible mechanisms describing the effects of arginine on virus inactivation using the current knowledge of aqueous arginine solution properties. |
topic |
virus inactivation arginine virus aggregation infectivity disinfectant |
url |
http://www.mdpi.com/1420-3049/15/3/1408/ |
work_keys_str_mv |
AT ahajimekoyama arginineasasynergisticvirucidalagent AT satoshiohtake arginineasasynergisticvirucidalagent AT tsutomuarakawa arginineasasynergisticvirucidalagent |
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