Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
Abstract Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies....
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doaj-753d155d08a1469f8d78cd926ae97da72021-04-11T11:31:46ZengNature Publishing GroupScientific Reports2045-23222021-04-0111111010.1038/s41598-021-87323-7Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomicsGeorgios Moros0Theodora Boutsikou1Charalambos Fotakis2Zoe Iliodromiti3Rozeta Sokou4Theodora Katsila5Theodoros Xanthos6Nicoletta Iacovidou7Panagiotis Zoumpoulakis8Department of Biochemistry & Biotechnology, University of ThessalyDepartment of Neonatology, National and Kapodistrian University of Athens, Aretaieio HospitalInstitute of Chemical Biology, National Hellenic Research FoundationDepartment of Neonatology, National and Kapodistrian University of Athens, Aretaieio HospitalDepartment of Neonatology, National and Kapodistrian University of Athens, Aretaieio HospitalInstitute of Chemical Biology, National Hellenic Research FoundationSchool of Medicine, European UniversityDepartment of Neonatology, National and Kapodistrian University of Athens, Aretaieio HospitalInstitute of Chemical Biology, National Hellenic Research FoundationAbstract Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies. Untargeted nuclear magnetic resonance (1H NMR) metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 IUGR and 36 appropriate for gestational age (AGA) deliveries. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) followed by pathway and enrichment analysis generated classification models and revealed significant metabolites that were associated with altered pathways. A clear association between maternal and cord blood altered metabolomic profile was evidenced in IUGR pregnancies. Increased levels of the amino acids alanine, leucine, valine, isoleucine and phenylalanine were prominent in IUGR pregnancies indicating a connection with impaired amino acid metabolism and transplacental flux. Tryptophan was individually connected with cord blood discrimination while 3-hydroxybutyrate assisted only maternal blood discrimination. Lower glycerol levels in IUGR samples ascribed to imbalance between gluconeogenesis and glycolysis pathways, suggesting poor glycolysis. The elevated levels of branched chain amino acids (leucine, isoleucine and valine) in intrauterine growth restricted pregnancies were linked with increased insulin resistance.https://doi.org/10.1038/s41598-021-87323-7 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Georgios Moros Theodora Boutsikou Charalambos Fotakis Zoe Iliodromiti Rozeta Sokou Theodora Katsila Theodoros Xanthos Nicoletta Iacovidou Panagiotis Zoumpoulakis |
spellingShingle |
Georgios Moros Theodora Boutsikou Charalambos Fotakis Zoe Iliodromiti Rozeta Sokou Theodora Katsila Theodoros Xanthos Nicoletta Iacovidou Panagiotis Zoumpoulakis Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics Scientific Reports |
author_facet |
Georgios Moros Theodora Boutsikou Charalambos Fotakis Zoe Iliodromiti Rozeta Sokou Theodora Katsila Theodoros Xanthos Nicoletta Iacovidou Panagiotis Zoumpoulakis |
author_sort |
Georgios Moros |
title |
Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics |
title_short |
Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics |
title_full |
Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics |
title_fullStr |
Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics |
title_full_unstemmed |
Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics |
title_sort |
insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-04-01 |
description |
Abstract Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies. Untargeted nuclear magnetic resonance (1H NMR) metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 IUGR and 36 appropriate for gestational age (AGA) deliveries. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) followed by pathway and enrichment analysis generated classification models and revealed significant metabolites that were associated with altered pathways. A clear association between maternal and cord blood altered metabolomic profile was evidenced in IUGR pregnancies. Increased levels of the amino acids alanine, leucine, valine, isoleucine and phenylalanine were prominent in IUGR pregnancies indicating a connection with impaired amino acid metabolism and transplacental flux. Tryptophan was individually connected with cord blood discrimination while 3-hydroxybutyrate assisted only maternal blood discrimination. Lower glycerol levels in IUGR samples ascribed to imbalance between gluconeogenesis and glycolysis pathways, suggesting poor glycolysis. The elevated levels of branched chain amino acids (leucine, isoleucine and valine) in intrauterine growth restricted pregnancies were linked with increased insulin resistance. |
url |
https://doi.org/10.1038/s41598-021-87323-7 |
work_keys_str_mv |
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