Relative survival in early-stage cancers in the Netherlands: a population-based study
Abstract In this nationwide, population-based study, we assessed 10-year relative survival among 225,305 patients with ten early-stage cancers diagnosed in the Netherlands during 2004–2015. This study aimed to ascertain which early-stage cancer is associated with minimal or no excess mortality and l...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-05-01
|
Series: | Journal of Hematology & Oncology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13045-020-00888-0 |
id |
doaj-754401f8b1ac4c5e8ed188f3183c2745 |
---|---|
record_format |
Article |
spelling |
doaj-754401f8b1ac4c5e8ed188f3183c27452020-11-25T02:05:55ZengBMCJournal of Hematology & Oncology1756-87222020-05-011311410.1186/s13045-020-00888-0Relative survival in early-stage cancers in the Netherlands: a population-based studyAvinash G. Dinmohamed0Valery E. P. P. Lemmens1Ignace H. J. T. de Hingh2Otto Visser3Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL)Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL)Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL)Department of Registration, Netherlands Comprehensive Cancer Organisation (IKNL)Abstract In this nationwide, population-based study, we assessed 10-year relative survival among 225,305 patients with ten early-stage cancers diagnosed in the Netherlands during 2004–2015. This study aimed to ascertain which early-stage cancer is associated with minimal or no excess mortality and likely to be diagnosed in individuals who are otherwise more healthy or health-conscious than their counterparts in the general population. Ten-year relative survival marginally exceeded 100% in patients with early-stage prostate cancer, while it was close to 100% for patients with ductal carcinoma in situ (DCIS) and stage I cancers of the breast, skin (melanoma), testis, and thyroid. In contrast, patients with early-stage oral/pharyngeal, bladder, lung, and pancreatic cancers experienced considerable excess mortality, reflected by a 10-year relative survival of 74.9%, 69.4%, 45.5%, and 33.9%, respectively. Collectively, the life expectancy of patients with DCIS and early-stage cancers of the prostate, breast, skin (melanoma), testis, and thyroid parallels the expected survival of an age-, sex-, and calendar year-matched group from the general population. Our study findings add to the controversy surrounding overdiagnosis of particular early-stage cancers that are generally not destined to metastasis or cause excess mortality.http://link.springer.com/article/10.1186/s13045-020-00888-0CancerRelative survivalEarly-stageEpidemiologyRegistryPopulation-based |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Avinash G. Dinmohamed Valery E. P. P. Lemmens Ignace H. J. T. de Hingh Otto Visser |
spellingShingle |
Avinash G. Dinmohamed Valery E. P. P. Lemmens Ignace H. J. T. de Hingh Otto Visser Relative survival in early-stage cancers in the Netherlands: a population-based study Journal of Hematology & Oncology Cancer Relative survival Early-stage Epidemiology Registry Population-based |
author_facet |
Avinash G. Dinmohamed Valery E. P. P. Lemmens Ignace H. J. T. de Hingh Otto Visser |
author_sort |
Avinash G. Dinmohamed |
title |
Relative survival in early-stage cancers in the Netherlands: a population-based study |
title_short |
Relative survival in early-stage cancers in the Netherlands: a population-based study |
title_full |
Relative survival in early-stage cancers in the Netherlands: a population-based study |
title_fullStr |
Relative survival in early-stage cancers in the Netherlands: a population-based study |
title_full_unstemmed |
Relative survival in early-stage cancers in the Netherlands: a population-based study |
title_sort |
relative survival in early-stage cancers in the netherlands: a population-based study |
publisher |
BMC |
series |
Journal of Hematology & Oncology |
issn |
1756-8722 |
publishDate |
2020-05-01 |
description |
Abstract In this nationwide, population-based study, we assessed 10-year relative survival among 225,305 patients with ten early-stage cancers diagnosed in the Netherlands during 2004–2015. This study aimed to ascertain which early-stage cancer is associated with minimal or no excess mortality and likely to be diagnosed in individuals who are otherwise more healthy or health-conscious than their counterparts in the general population. Ten-year relative survival marginally exceeded 100% in patients with early-stage prostate cancer, while it was close to 100% for patients with ductal carcinoma in situ (DCIS) and stage I cancers of the breast, skin (melanoma), testis, and thyroid. In contrast, patients with early-stage oral/pharyngeal, bladder, lung, and pancreatic cancers experienced considerable excess mortality, reflected by a 10-year relative survival of 74.9%, 69.4%, 45.5%, and 33.9%, respectively. Collectively, the life expectancy of patients with DCIS and early-stage cancers of the prostate, breast, skin (melanoma), testis, and thyroid parallels the expected survival of an age-, sex-, and calendar year-matched group from the general population. Our study findings add to the controversy surrounding overdiagnosis of particular early-stage cancers that are generally not destined to metastasis or cause excess mortality. |
topic |
Cancer Relative survival Early-stage Epidemiology Registry Population-based |
url |
http://link.springer.com/article/10.1186/s13045-020-00888-0 |
work_keys_str_mv |
AT avinashgdinmohamed relativesurvivalinearlystagecancersinthenetherlandsapopulationbasedstudy AT valeryepplemmens relativesurvivalinearlystagecancersinthenetherlandsapopulationbasedstudy AT ignacehjtdehingh relativesurvivalinearlystagecancersinthenetherlandsapopulationbasedstudy AT ottovisser relativesurvivalinearlystagecancersinthenetherlandsapopulationbasedstudy |
_version_ |
1724936166857244672 |