Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1

Insulin Signaling as a Key Moderator in Myotonic Dystrophy Type 1

Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease characterized by multi-system involvement. Affected organ system includes skeletal muscle, heart, gastro-intestinal system and the brain. In this review, we evaluate the evidence for alterations in insulin signaling and their r...

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Bibliographic Details
Main Authors: Sylvia Nieuwenhuis, Kees Okkersen, Joanna Widomska, Paul Blom, Peter A. C. 't Hoen, Baziel van Engelen, Jeffrey C. Glennon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neurology
Subjects:
insulin
myotonic dystrophy (DM1)
insulin-like growth factor 1 (IGF1)
metformin
diabetes type 2
insulin resistance
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01229/full

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