Association between ovarian reserve and preeclampsia: a cohort study
Abstract Background The risk of cardiovascular disease in women increases after menopause. It has been shown that women with lower pre-menopausal ovarian reserve may experience increased cardiovascular risk. We sought to determine whether there is any association between ovarian reserve, as assessed...
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doaj-75539ac0685d4a5fa81c7ba97e7030682020-11-25T04:09:53ZengBMCBMC Pregnancy and Childbirth1471-23932019-11-011911810.1186/s12884-019-2578-yAssociation between ovarian reserve and preeclampsia: a cohort studyHadi Erfani0Maryam Rahmati1Mohammad Ali Mansournia2Fereidoun Azizi3Seyed Ali Montazeri4Alireza A. Shamshirsaz5Fahimeh Ramezani Tehrani6Department of Obstetrics and Gynecology, Baylor College of MedicineReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical SciencesReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesDepartment of Obstetrics and Gynecology, Baylor College of MedicineReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesAbstract Background The risk of cardiovascular disease in women increases after menopause. It has been shown that women with lower pre-menopausal ovarian reserve may experience increased cardiovascular risk. We sought to determine whether there is any association between ovarian reserve, as assessed by Anti-Mullerian hormone (AMH), and preeclampsia (PE). Methods Subjects of this study were selected from among participants of the Tehran Lipid and Glucose Study (TLGS), a population-based cohort with a 15-year follow-up (1998–2014). Out of 2412 women aged 20–50 years, there were 781 women who met eligibility criteria, including having comprehensive data on their reproductive assessment and ovarian reserve status, identified based on age-specific AMH levels according to the exponential–normal three-parameter model that was measured before pregnancy. There were 80 and 701 participants in the preeclampsia and non-PE groups, respectively. The association between dichotomous outcome variable PE and age-specific AMH quartiles was evaluated using pooled logistic regression. Results PE was observed in 23 (11.1%), 12 (6.4%), 26 (13.3%) and 19 (10%) women in the 1st, 2nd, 3rd and 4th quartiles of pre-pregnancy age-specific AMH, respectively (P = 0.16). Median and inter-quartile range of serum AMH levels was 1.05 (0.36–2.2) mg/L in women who experienced PE compared with 0.85 (0.28–2.1) mg/L in women with normotensive pregnancies (P = 0.53). Based on the pooled logistic regression analysis, the effect of age-specific AMH quartiles on PE progression (adjusted for age, BMI, smoking status, and family history of hypertension) were not significant (OR1st vs 4th: 1.5, P-value: 0.1, CI: (0.9, 2.4)). Conclusions Age-specific AMH may not be a suitable marker for prediction of PE. Further longitudinal studies, considering pre-conception measurement of AMH, are recommended for better interpretation of the association between ovarian reserve status and PE.http://link.springer.com/article/10.1186/s12884-019-2578-yAnti-Mullerian hormoneOvarian reservePre-Eclampsia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hadi Erfani Maryam Rahmati Mohammad Ali Mansournia Fereidoun Azizi Seyed Ali Montazeri Alireza A. Shamshirsaz Fahimeh Ramezani Tehrani |
spellingShingle |
Hadi Erfani Maryam Rahmati Mohammad Ali Mansournia Fereidoun Azizi Seyed Ali Montazeri Alireza A. Shamshirsaz Fahimeh Ramezani Tehrani Association between ovarian reserve and preeclampsia: a cohort study BMC Pregnancy and Childbirth Anti-Mullerian hormone Ovarian reserve Pre-Eclampsia |
author_facet |
Hadi Erfani Maryam Rahmati Mohammad Ali Mansournia Fereidoun Azizi Seyed Ali Montazeri Alireza A. Shamshirsaz Fahimeh Ramezani Tehrani |
author_sort |
Hadi Erfani |
title |
Association between ovarian reserve and preeclampsia: a cohort study |
title_short |
Association between ovarian reserve and preeclampsia: a cohort study |
title_full |
Association between ovarian reserve and preeclampsia: a cohort study |
title_fullStr |
Association between ovarian reserve and preeclampsia: a cohort study |
title_full_unstemmed |
Association between ovarian reserve and preeclampsia: a cohort study |
title_sort |
association between ovarian reserve and preeclampsia: a cohort study |
publisher |
BMC |
series |
BMC Pregnancy and Childbirth |
issn |
1471-2393 |
publishDate |
2019-11-01 |
description |
Abstract Background The risk of cardiovascular disease in women increases after menopause. It has been shown that women with lower pre-menopausal ovarian reserve may experience increased cardiovascular risk. We sought to determine whether there is any association between ovarian reserve, as assessed by Anti-Mullerian hormone (AMH), and preeclampsia (PE). Methods Subjects of this study were selected from among participants of the Tehran Lipid and Glucose Study (TLGS), a population-based cohort with a 15-year follow-up (1998–2014). Out of 2412 women aged 20–50 years, there were 781 women who met eligibility criteria, including having comprehensive data on their reproductive assessment and ovarian reserve status, identified based on age-specific AMH levels according to the exponential–normal three-parameter model that was measured before pregnancy. There were 80 and 701 participants in the preeclampsia and non-PE groups, respectively. The association between dichotomous outcome variable PE and age-specific AMH quartiles was evaluated using pooled logistic regression. Results PE was observed in 23 (11.1%), 12 (6.4%), 26 (13.3%) and 19 (10%) women in the 1st, 2nd, 3rd and 4th quartiles of pre-pregnancy age-specific AMH, respectively (P = 0.16). Median and inter-quartile range of serum AMH levels was 1.05 (0.36–2.2) mg/L in women who experienced PE compared with 0.85 (0.28–2.1) mg/L in women with normotensive pregnancies (P = 0.53). Based on the pooled logistic regression analysis, the effect of age-specific AMH quartiles on PE progression (adjusted for age, BMI, smoking status, and family history of hypertension) were not significant (OR1st vs 4th: 1.5, P-value: 0.1, CI: (0.9, 2.4)). Conclusions Age-specific AMH may not be a suitable marker for prediction of PE. Further longitudinal studies, considering pre-conception measurement of AMH, are recommended for better interpretation of the association between ovarian reserve status and PE. |
topic |
Anti-Mullerian hormone Ovarian reserve Pre-Eclampsia |
url |
http://link.springer.com/article/10.1186/s12884-019-2578-y |
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