Free radical-mediated cytosine C-5 methylation triggers epigenetic changes during carcinogenesis
The methylation of the C-5 position of deoxycytidine (dC) in the promoter regions of tumor suppressor genes is often observed in cancer cells. We found that various environmental agents, as well as endogenous compounds such as methionine sulfoxide (MetO), generate methyl radicals and modify dC to fo...
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Online Access: | https://doi.org/10.1515/bmc-2012-0052 |
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doaj-755450c56d7f4f728dbb6cbae80974712021-09-05T20:42:33ZengDe GruyterBiomolecular Concepts1868-50211868-503X2013-06-014321322010.1515/bmc-2012-0052Free radical-mediated cytosine C-5 methylation triggers epigenetic changes during carcinogenesisKasai Hiroshi0Kawai Kazuaki1Li Yun-Shan2Institute of Industrial Ecological Sciences, Department of Environmental Oncology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, JapanInstitute of Industrial Ecological Sciences, Department of Environmental Oncology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, JapanInstitute of Industrial Ecological Sciences, Department of Environmental Oncology, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, JapanThe methylation of the C-5 position of deoxycytidine (dC) in the promoter regions of tumor suppressor genes is often observed in cancer cells. We found that various environmental agents, as well as endogenous compounds such as methionine sulfoxide (MetO), generate methyl radicals and modify dC to form 5-methyl-dC in DNA in vitro. We confirmed that both DNA methylation and cancer incidence in the liver were increased by the administration of MetO to oxidatively stressed mice. In this review, we summarize previous reports on methyl radical generation in vitro and in vivo and DNA modifications by methyl radicals, including our discoveries, as well as our recent experimental evidence suggesting that free radical-mediated dC methylation triggers epigenetic changes.https://doi.org/10.1515/bmc-2012-00525-methyldeoxycytidinedna methylationepigeneticmethyl radical |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kasai Hiroshi Kawai Kazuaki Li Yun-Shan |
spellingShingle |
Kasai Hiroshi Kawai Kazuaki Li Yun-Shan Free radical-mediated cytosine C-5 methylation triggers epigenetic changes during carcinogenesis Biomolecular Concepts 5-methyldeoxycytidine dna methylation epigenetic methyl radical |
author_facet |
Kasai Hiroshi Kawai Kazuaki Li Yun-Shan |
author_sort |
Kasai Hiroshi |
title |
Free radical-mediated cytosine C-5 methylation triggers epigenetic changes during carcinogenesis |
title_short |
Free radical-mediated cytosine C-5 methylation triggers epigenetic changes during carcinogenesis |
title_full |
Free radical-mediated cytosine C-5 methylation triggers epigenetic changes during carcinogenesis |
title_fullStr |
Free radical-mediated cytosine C-5 methylation triggers epigenetic changes during carcinogenesis |
title_full_unstemmed |
Free radical-mediated cytosine C-5 methylation triggers epigenetic changes during carcinogenesis |
title_sort |
free radical-mediated cytosine c-5 methylation triggers epigenetic changes during carcinogenesis |
publisher |
De Gruyter |
series |
Biomolecular Concepts |
issn |
1868-5021 1868-503X |
publishDate |
2013-06-01 |
description |
The methylation of the C-5 position of deoxycytidine (dC) in the promoter regions of tumor suppressor genes is often observed in cancer cells. We found that various environmental agents, as well as endogenous compounds such as methionine sulfoxide (MetO), generate methyl radicals and modify dC to form 5-methyl-dC in DNA in vitro. We confirmed that both DNA methylation and cancer incidence in the liver were increased by the administration of MetO to oxidatively stressed mice. In this review, we summarize previous reports on methyl radical generation in vitro and in vivo and DNA modifications by methyl radicals, including our discoveries, as well as our recent experimental evidence suggesting that free radical-mediated dC methylation triggers epigenetic changes. |
topic |
5-methyldeoxycytidine dna methylation epigenetic methyl radical |
url |
https://doi.org/10.1515/bmc-2012-0052 |
work_keys_str_mv |
AT kasaihiroshi freeradicalmediatedcytosinec5methylationtriggersepigeneticchangesduringcarcinogenesis AT kawaikazuaki freeradicalmediatedcytosinec5methylationtriggersepigeneticchangesduringcarcinogenesis AT liyunshan freeradicalmediatedcytosinec5methylationtriggersepigeneticchangesduringcarcinogenesis |
_version_ |
1717785535477448704 |