Secondary Metabolites with <i>α</i>-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp. CY-3

Secondary Metabolites with <i>α</i>-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp. CY-3

Eight new compounds, including two sambutoxin derivatives (<b>1</b>–<b>2</b>), two highly oxygenated cyclopentenones (<b>7</b>–<b>8</b>), four highly oxygenated cyclohexenones (<b>9</b>–<b>12</b>), together with four known sambu...

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Main Authors: Wencong Yang, Qi Tan, Yihao Yin, Yan Chen, Yi Zhang, Jianying Wu, Leyao Gao, Bo Wang, Zhigang She
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Marine Drugs
Subjects:
<i>Talaromyces</i> sp.
molecular networking
sambutoxin
polyketides
<i>α</i>-glucosidase
Online Access:https://www.mdpi.com/1660-3397/19/9/492
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spelling doaj-7555660442d64a4594fd24c50b04b5922021-09-26T00:35:27ZengMDPI AGMarine Drugs1660-33972021-08-011949249210.3390/md19090492Secondary Metabolites with <i>α</i>-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp. CY-3Wencong Yang0Qi Tan1Yihao Yin2Yan Chen3Yi Zhang4Jianying Wu5Leyao Gao6Bo Wang7Zhigang She8School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaResearch Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaSchool of Chemistry, Sun Yat-Sen University, Guangzhou 510275, ChinaEight new compounds, including two sambutoxin derivatives (<b>1</b>–<b>2</b>), two highly oxygenated cyclopentenones (<b>7</b>–<b>8</b>), four highly oxygenated cyclohexenones (<b>9</b>–<b>12</b>), together with four known sambutoxin derivatives (<b>3</b>–<b>6</b>), were isolated from semimangrove endophytic fungus <i>Talaromyces</i> sp. CY-3, under the guidance of molecular networking. The structures of new isolates were elucidated by analysis of detailed spectroscopic data, ECD spectra, chemical hydrolysis, <sup>13</sup>C NMR calculation, and DP4+ analysis. In bioassays, compounds <b>1</b>–<b>5</b> displayed better <i>α</i>-glucosidase inhibitory activity than the positive control 1-deoxynojirimycin (IC<sub>50</sub> = 80.8 ± 0.3 μM), and the IC<sub>50</sub> value was in the range of 12.6 ± 0.9 to 57.3 ± 1.3 μM.https://www.mdpi.com/1660-3397/19/9/492<i>Talaromyces</i> sp.molecular networkingsambutoxinpolyketides<i>α</i>-glucosidase
collection DOAJ
language English
format Article
sources DOAJ
author Wencong Yang
Qi Tan
Yihao Yin
Yan Chen
Yi Zhang
Jianying Wu
Leyao Gao
Bo Wang
Zhigang She
spellingShingle Wencong Yang
Qi Tan
Yihao Yin
Yan Chen
Yi Zhang
Jianying Wu
Leyao Gao
Bo Wang
Zhigang She
Secondary Metabolites with <i>α</i>-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp. CY-3
Marine Drugs
<i>Talaromyces</i> sp.
molecular networking
sambutoxin
polyketides
<i>α</i>-glucosidase
author_facet Wencong Yang
Qi Tan
Yihao Yin
Yan Chen
Yi Zhang
Jianying Wu
Leyao Gao
Bo Wang
Zhigang She
author_sort Wencong Yang
title Secondary Metabolites with <i>α</i>-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp. CY-3
title_short Secondary Metabolites with <i>α</i>-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp. CY-3
title_full Secondary Metabolites with <i>α</i>-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp. CY-3
title_fullStr Secondary Metabolites with <i>α</i>-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp. CY-3
title_full_unstemmed Secondary Metabolites with <i>α</i>-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus <i>Talaromyces</i> sp. CY-3
title_sort secondary metabolites with <i>α</i>-glucosidase inhibitory activity from mangrove endophytic fungus <i>talaromyces</i> sp. cy-3
publisher MDPI AG
series Marine Drugs
issn 1660-3397
publishDate 2021-08-01
description Eight new compounds, including two sambutoxin derivatives (<b>1</b>–<b>2</b>), two highly oxygenated cyclopentenones (<b>7</b>–<b>8</b>), four highly oxygenated cyclohexenones (<b>9</b>–<b>12</b>), together with four known sambutoxin derivatives (<b>3</b>–<b>6</b>), were isolated from semimangrove endophytic fungus <i>Talaromyces</i> sp. CY-3, under the guidance of molecular networking. The structures of new isolates were elucidated by analysis of detailed spectroscopic data, ECD spectra, chemical hydrolysis, <sup>13</sup>C NMR calculation, and DP4+ analysis. In bioassays, compounds <b>1</b>–<b>5</b> displayed better <i>α</i>-glucosidase inhibitory activity than the positive control 1-deoxynojirimycin (IC<sub>50</sub> = 80.8 ± 0.3 μM), and the IC<sub>50</sub> value was in the range of 12.6 ± 0.9 to 57.3 ± 1.3 μM.
topic <i>Talaromyces</i> sp.
molecular networking
sambutoxin
polyketides
<i>α</i>-glucosidase
url https://www.mdpi.com/1660-3397/19/9/492
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