Simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study
Abstract Background This study aimed to compare and validate the out-of-hospital cardiac arrest (OHCA); cardiac arrest hospital prognosis (CAHP); non-shockable rhythm, unwitnessed arrest, long no-flow or long low-flow period, blood pH < 7.2, lactate > 7.0 mmol/L, end-stage chronic kidney disea...
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doaj-7555c7a42b5b429092bdb2d8478f4f352021-08-15T11:18:24ZengBMCScandinavian Journal of Trauma, Resuscitation and Emergency Medicine1757-72412021-08-012911810.1186/s13049-021-00935-wSimultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective studyTakumi Tsuchida0Kota Ono1Kunihiko Maekawa2Takeshi Wada3Kenichi Katabami4Tomonao Yoshida5Mineji Hayakawa6Department of Emergency Medicine, Hokkaido University HospitalOno Biostat ConsultingDepartment of Emergency Medicine, Hokkaido University HospitalDepartment of Emergency Medicine, Hokkaido University HospitalDepartment of Emergency Medicine, Hokkaido University HospitalDepartment of Emergency Medicine, Hokkaido University HospitalDepartment of Emergency Medicine, Hokkaido University HospitalAbstract Background This study aimed to compare and validate the out-of-hospital cardiac arrest (OHCA); cardiac arrest hospital prognosis (CAHP); non-shockable rhythm, unwitnessed arrest, long no-flow or long low-flow period, blood pH < 7.2, lactate > 7.0 mmol/L, end-stage chronic kidney disease, age ≥ 85 years, still resuscitation, and extracardiac cause (NULL-PLEASE) clinical; post-cardiac arrest syndrome for therapeutic hypothermia (CAST); and revised CAST (rCAST) scores in OHCA patients treated with recent cardiopulmonary resuscitation strategies. Methods We retrospectively collected data on adult OHCA patients admitted to our emergency department between February 2015 and July 2018. OHCA, CAHP, NULL-PLEASE clinical, CAST, and rCAST scores were calculated based on the data collected. The predictive abilities of each score were tested using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Results We identified 236 OHCA patients from computer-based medical records and analyzed 189 without missing data. In OHCA patients without bystander witnesses, CAHP and OHCA scores were not calculated. Although the predictive abilities of the scores were not significantly different, the NULL-PLEASE score had a large AUC of ROC curve in various OHCA patients. Furthermore, in patients with bystander-witnessed OHCA, the NULL-PLEASE score had large partial AUCs of ROC from sensitivity 0.8–1.0 and specificity 0.8–1.0. Conclusions The NULL-PLEASE score had a high, comprehensive predictive ability in various OHCA patients. Furthermore, the NULL-PLEASE score had a high predictive ability for good and poor neurological outcomes in patients with bystander-witnessed OHCA.https://doi.org/10.1186/s13049-021-00935-wOut-of-hospital cardiac arrestPredictionPrognosisNeurological outcome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takumi Tsuchida Kota Ono Kunihiko Maekawa Takeshi Wada Kenichi Katabami Tomonao Yoshida Mineji Hayakawa |
spellingShingle |
Takumi Tsuchida Kota Ono Kunihiko Maekawa Takeshi Wada Kenichi Katabami Tomonao Yoshida Mineji Hayakawa Simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine Out-of-hospital cardiac arrest Prediction Prognosis Neurological outcome |
author_facet |
Takumi Tsuchida Kota Ono Kunihiko Maekawa Takeshi Wada Kenichi Katabami Tomonao Yoshida Mineji Hayakawa |
author_sort |
Takumi Tsuchida |
title |
Simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study |
title_short |
Simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study |
title_full |
Simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study |
title_fullStr |
Simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study |
title_full_unstemmed |
Simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study |
title_sort |
simultaneous external validation of various cardiac arrest prognostic scores: a single-center retrospective study |
publisher |
BMC |
series |
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine |
issn |
1757-7241 |
publishDate |
2021-08-01 |
description |
Abstract Background This study aimed to compare and validate the out-of-hospital cardiac arrest (OHCA); cardiac arrest hospital prognosis (CAHP); non-shockable rhythm, unwitnessed arrest, long no-flow or long low-flow period, blood pH < 7.2, lactate > 7.0 mmol/L, end-stage chronic kidney disease, age ≥ 85 years, still resuscitation, and extracardiac cause (NULL-PLEASE) clinical; post-cardiac arrest syndrome for therapeutic hypothermia (CAST); and revised CAST (rCAST) scores in OHCA patients treated with recent cardiopulmonary resuscitation strategies. Methods We retrospectively collected data on adult OHCA patients admitted to our emergency department between February 2015 and July 2018. OHCA, CAHP, NULL-PLEASE clinical, CAST, and rCAST scores were calculated based on the data collected. The predictive abilities of each score were tested using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Results We identified 236 OHCA patients from computer-based medical records and analyzed 189 without missing data. In OHCA patients without bystander witnesses, CAHP and OHCA scores were not calculated. Although the predictive abilities of the scores were not significantly different, the NULL-PLEASE score had a large AUC of ROC curve in various OHCA patients. Furthermore, in patients with bystander-witnessed OHCA, the NULL-PLEASE score had large partial AUCs of ROC from sensitivity 0.8–1.0 and specificity 0.8–1.0. Conclusions The NULL-PLEASE score had a high, comprehensive predictive ability in various OHCA patients. Furthermore, the NULL-PLEASE score had a high predictive ability for good and poor neurological outcomes in patients with bystander-witnessed OHCA. |
topic |
Out-of-hospital cardiac arrest Prediction Prognosis Neurological outcome |
url |
https://doi.org/10.1186/s13049-021-00935-w |
work_keys_str_mv |
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