Anticholinesterase and Antityrosinase Activities of Ten Piper Species from Malaysia

• Main Authors: Wan Mohd Nuzul Hakimi Wan Salleh, Nur Athirah Hashim, Farediah Ahmad, Khong Heng Yen
• Format: Article
• Language: English
• Published: Tabriz University of Medical Sciences 2014-12-01
• Series: Advanced Pharmaceutical Bulletin
• Subjects: Anticholinesterase; Antityrosinase; Piper; Piper erecticaule; Piper porphyrophyllum; Piperaceae
• Online Access: http://journals.tbzmed.ac.ir/APB/Manuscript/APB-4-527.pdf
• ISSN: 2228-5881; 2251-7308

Purpose: The aim of this study was to investigate acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and antityrosinase activities of extracts from ten Piper species namely; P. caninum, P. lanatum, P. abbreviatum, P. aborescens, P. porphyrophyllum, P. erecticaule, P. ribesioides, P. miniatum, P. stylosum, and P. majusculum. Methods: Anticholinesterase and antityrosinase activities were evaluated against in vitro Ellman spectroscopy method and mushroom tyrosinase, respectively. Results: The EtOAc extract of P. erecticaule showed the highest AChE and BChE inhibitory with 22.9% and 70.9% inhibition, respectively. In antityrosinase activity, all extracts of P. porphyrophyllum showed the highest inhibitory effects against mushroom tyrosinase, compared to standard, kojic acid. Conclusion: This study showed that P. erecticaule and P. porphyrophyllum have potential AChE/BChE and tyrosinase inhibition activities. The respective extracts can be explored further for the development of novel lead as AChE/BChE and tyrosinase inhibitors in therapeutic management of Alzheimer’s disease.