Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s Disease
The relationship quality, mutuality, has been identified as a protective factor in family care situations, but its role in mediating health-related quality of life (HRQoL) in patients having Parkinson’s disease (PD) is not known. Data on patients’ and partners’ mutuality (MS), motor signs (UPDRS III...
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doaj-75588855537f4b42bc9c53983b5ada262020-11-25T02:27:50ZengHindawi LimitedParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/95486819548681Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s DiseaseMichaela Karlstedt0Seyed-Mohammad Fereshtehnejad1Dag Aarsland2Johan Lökk3Karolinska Institutet, Department of Neurobiology Care Sciences and Society, Division of Clinical Geriatrics, Floor 7 141 83 Huddinge, Stockholm, SwedenKarolinska Institutet, Department of Neurobiology Care Sciences and Society, Division of Clinical Geriatrics, Floor 7 141 83 Huddinge, Stockholm, SwedenKarolinska Institutet, Alzheimer Disease Research Center (KI-ADRC) Novum, Floor 5 SE-141 86, Stockholm, SwedenKarolinska Institutet, Department of Neurobiology Care Sciences and Society, Division of Clinical Geriatrics, Floor 7 141 83 Huddinge, Stockholm, SwedenThe relationship quality, mutuality, has been identified as a protective factor in family care situations, but its role in mediating health-related quality of life (HRQoL) in patients having Parkinson’s disease (PD) is not known. Data on patients’ and partners’ mutuality (MS), motor signs (UPDRS III), non-motor symptoms (NMSQuest), impaired cognition (IQCODE), dependency in activities of daily life (ADL), and HRQoL (PDQ8) were collected from 51 dyads. Structural equation model with manifest variables was applied to explore if the MS score mediated the effect of UPDRS III, NMSQuest, IQCODE, and dependency in ADL on PDQ8. The results suggest that increasing severity of motor and non-motor symptoms decreases patients’ mutuality which leads to worse HRQoL. Partners’ mutuality mediated the effect of impaired cognition which in turn decreased patients’ mutuality. The findings enhance our understanding of how various symptoms may influence PD patients’ HRQoL. This may help clinicians to personalize interventions to provide more effective interventions to improve the lives of patients with PD.http://dx.doi.org/10.1155/2018/9548681 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michaela Karlstedt Seyed-Mohammad Fereshtehnejad Dag Aarsland Johan Lökk |
spellingShingle |
Michaela Karlstedt Seyed-Mohammad Fereshtehnejad Dag Aarsland Johan Lökk Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s Disease Parkinson's Disease |
author_facet |
Michaela Karlstedt Seyed-Mohammad Fereshtehnejad Dag Aarsland Johan Lökk |
author_sort |
Michaela Karlstedt |
title |
Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s Disease |
title_short |
Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s Disease |
title_full |
Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s Disease |
title_fullStr |
Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s Disease |
title_full_unstemmed |
Mediating Effect of Mutuality on Health-Related Quality of Life in Patients with Parkinson’s Disease |
title_sort |
mediating effect of mutuality on health-related quality of life in patients with parkinson’s disease |
publisher |
Hindawi Limited |
series |
Parkinson's Disease |
issn |
2090-8083 2042-0080 |
publishDate |
2018-01-01 |
description |
The relationship quality, mutuality, has been identified as a protective factor in family care situations, but its role in mediating health-related quality of life (HRQoL) in patients having Parkinson’s disease (PD) is not known. Data on patients’ and partners’ mutuality (MS), motor signs (UPDRS III), non-motor symptoms (NMSQuest), impaired cognition (IQCODE), dependency in activities of daily life (ADL), and HRQoL (PDQ8) were collected from 51 dyads. Structural equation model with manifest variables was applied to explore if the MS score mediated the effect of UPDRS III, NMSQuest, IQCODE, and dependency in ADL on PDQ8. The results suggest that increasing severity of motor and non-motor symptoms decreases patients’ mutuality which leads to worse HRQoL. Partners’ mutuality mediated the effect of impaired cognition which in turn decreased patients’ mutuality. The findings enhance our understanding of how various symptoms may influence PD patients’ HRQoL. This may help clinicians to personalize interventions to provide more effective interventions to improve the lives of patients with PD. |
url |
http://dx.doi.org/10.1155/2018/9548681 |
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