High serum non-high-density lipoprotein and the risk of ischemic stroke: A systematic review
Objectives. High levels of non high density lipoprotein cholesterol (non-HDL-C) are known to contribute to an increased risk of ischemic stroke. This systematic review was conducted to identify the relationship between high non-HDL-C levels and the risk of ischemic stroke. Material and methods. Thi...
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doaj-755f48b446f8446e9e7e82650b06856c2021-08-13T07:57:55ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942021-03-01201152010.37897/RJN.2021.1.2High serum non-high-density lipoprotein and the risk of ischemic stroke: A systematic reviewNyoman Tyas Apsari0Kumara Tini1I Putu Eka Widyadharma2Faculty of Medicine, Udayana University, Bali, IndonesiaFaculty of Medicine, Udayana University, Bali, Indonesia; Department of Neurology, Sanglah Hospital, Bali, IndonesiaFaculty of Medicine, Udayana University, Bali, Indonesia; Department of Neurology, Sanglah Hospital, Bali, IndonesiaObjectives. High levels of non high density lipoprotein cholesterol (non-HDL-C) are known to contribute to an increased risk of ischemic stroke. This systematic review was conducted to identify the relationship between high non-HDL-C levels and the risk of ischemic stroke. Material and methods. This systematic review using PRISMA (preferred reporting items for systematic reviews and meta-analyses) statement guideline, with a pre-determined search strategy. The search was conducted in Pubmed Central (PMC) and Pubmed from 2009 until 2020 with inclusion criteria, patients with a diagnosis of ischemic stroke, age >18 years, with non-HDL-C levels. The title and abstract of these articles were reviewed for relevance, based on inclusion criteria. This systematic review using STROBE to evaluate the quality in individual study which consists of 22 domains. Results. In the final stage, this systematic review identifies six cohort study consisting 166.720 participants. Overall, the quality in individual studies based on STROBE is good. We reported that there are two studies report that high non-HDL-C levels can significantly increase the risk of ischemic stroke. Meanwhile, there are four studies that report there was no significant relationship between high non-HDL-C levels and the risk of ischemic stroke. Conclusions. Overall, this systematic review provides the result about relationship between high levels of non-HDL-C and the risk of ischemic stroke, there are two studies with a larger population support that high levels of non-HDL-C can increase the risk of ischemic stroke. However, further studies is needed with a large population that specifically identify the relationship between non-HDL-C levels and risk of ischemic stroke and makes a better adjustments for confounding variables.https://rjn.com.ro/articles/2021.1/RJN_2021_1_Art-02.pdfischemic strokenon-hdl-crisk |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nyoman Tyas Apsari Kumara Tini I Putu Eka Widyadharma |
spellingShingle |
Nyoman Tyas Apsari Kumara Tini I Putu Eka Widyadharma High serum non-high-density lipoprotein and the risk of ischemic stroke: A systematic review Romanian Journal of Neurology ischemic stroke non-hdl-c risk |
author_facet |
Nyoman Tyas Apsari Kumara Tini I Putu Eka Widyadharma |
author_sort |
Nyoman Tyas Apsari |
title |
High serum non-high-density lipoprotein and the risk of ischemic stroke: A systematic review |
title_short |
High serum non-high-density lipoprotein and the risk of ischemic stroke: A systematic review |
title_full |
High serum non-high-density lipoprotein and the risk of ischemic stroke: A systematic review |
title_fullStr |
High serum non-high-density lipoprotein and the risk of ischemic stroke: A systematic review |
title_full_unstemmed |
High serum non-high-density lipoprotein and the risk of ischemic stroke: A systematic review |
title_sort |
high serum non-high-density lipoprotein and the risk of ischemic stroke: a systematic review |
publisher |
Amaltea Medical Publishing House |
series |
Romanian Journal of Neurology |
issn |
1843-8148 2069-6094 |
publishDate |
2021-03-01 |
description |
Objectives. High levels of non high density lipoprotein cholesterol (non-HDL-C) are known to contribute to an increased risk of ischemic stroke. This systematic review was conducted to identify the relationship between high non-HDL-C levels and the risk of ischemic stroke.
Material and methods. This systematic review using PRISMA (preferred reporting items for systematic reviews and meta-analyses) statement guideline, with a pre-determined search strategy. The search was conducted in Pubmed Central (PMC) and Pubmed from 2009 until 2020 with inclusion criteria, patients with a diagnosis of ischemic stroke, age >18 years, with non-HDL-C levels. The title and abstract of these articles were reviewed for relevance, based on inclusion criteria. This systematic review using STROBE to evaluate the quality in individual study which consists of 22 domains.
Results. In the final stage, this systematic review identifies six cohort study consisting 166.720 participants. Overall, the quality in individual studies based on STROBE is good. We reported that there are two studies report that high non-HDL-C levels can significantly increase the risk of ischemic stroke. Meanwhile, there are four studies that report there was no significant relationship between high non-HDL-C levels and the risk of ischemic stroke.
Conclusions. Overall, this systematic review provides the result about relationship between high levels of non-HDL-C and the risk of ischemic stroke, there are two studies with a larger population support that high levels of non-HDL-C can increase the risk of ischemic stroke. However, further studies is needed with a large population that specifically identify the relationship between non-HDL-C levels and risk of ischemic stroke and makes a better adjustments for confounding variables. |
topic |
ischemic stroke non-hdl-c risk |
url |
https://rjn.com.ro/articles/2021.1/RJN_2021_1_Art-02.pdf |
work_keys_str_mv |
AT nyomantyasapsari highserumnonhighdensitylipoproteinandtheriskofischemicstrokeasystematicreview AT kumaratini highserumnonhighdensitylipoproteinandtheriskofischemicstrokeasystematicreview AT iputuekawidyadharma highserumnonhighdensitylipoproteinandtheriskofischemicstrokeasystematicreview |
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