Prognostic factors associated with in-hospital mortality in patients with spontaneous bacterial peritonitis
Introduction. Spontaneous bacterial peritonitis (SBP) is associated with a high in-hospital mortality rate ranging from 20-40%. The model for end-stage liver disease (MELD) has been suggested as a predictor of inhospital mortality in patients with SBP. However, the accuracy of the MELD has been ques...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2012-11-01
|
Series: | Annals of Hepatology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119314188 |
id |
doaj-756389ab063d4ddbb8b1fec6a6fc8ab5 |
---|---|
record_format |
Article |
spelling |
doaj-756389ab063d4ddbb8b1fec6a6fc8ab52021-06-09T05:54:33ZengElsevierAnnals of Hepatology1665-26812012-11-01116915920Prognostic factors associated with in-hospital mortality in patients with spontaneous bacterial peritonitisMaiara Isabel Musskopf0Fabricio Pimentel Fonseca1Jeferson Gass2Angelo Zambam de Mattos3Jorge Alberto John4Ajacio Bandeira de Mello Brandao, M.D.5Gastroenterology and Hepatology Residency Program, Universidade Federal de Ciencias da Saude de Porto Alegre (UFCSPA), Porto Alegre, RS, BrazilInternal Medicine Residency Program, UFCSPA, Porto Alegre, RS, BrazilPost-Graduate Program in Medicine: Hepatology, UFCSPA, Porto Alegre, RS, BrazilPost-Graduate Program in Medicine: Hepatology, UFCSPA, Porto Alegre, RS, BrazilPost-Graduate Program in Medicine: Hepatology, UFCSPA, Porto Alegre, RS, BrazilPost-Graduate Program in Medicine: Hepatology, UFCSPA, Porto Alegre, RS, Brazil; Correspondence and reprint request:Introduction. Spontaneous bacterial peritonitis (SBP) is associated with a high in-hospital mortality rate ranging from 20-40%. The model for end-stage liver disease (MELD) has been suggested as a predictor of inhospital mortality in patients with SBP. However, the accuracy of the MELD has been questioned, and the integrated MELD (iMELD) score, which incorporates age and serum sodium to the previous model, has been proposed to improve prognostic accuracy. The iMELD has not yet been evaluated in patients with SBP.Aim. To evaluate the accuracy of iMELD and MELD scores in predicting in-hospital mortality in patients with SBP and to identify other prognostic factors of mortality in this group of patients.Results. Of 40 patients analyzed, 65% were male, 50% had hepatitis C, and 27.5% had hepatocellular carcinoma. Mean age was 55.6 years; 25.7% were classified as Child-Pugh class B, and 74.3% as class C. Mean scores were 46.0 and 19.9 for iMELD and MELD, respectively. In-hospital mortality was 40%. Univariate analysis showed that total bilirubin, creatinine, MELD and iMELD scores were significantly associated with in-hospital mortality. The prognostic accuracy was 80% and 77% for iMELD and MELD scores, respectively.Conclusion. In conclusion, bilirubin, creatinine, MELD and iMELD were predictors of in-hospital mortality in cirrhotic patients with SPB. iMELD was slightly more accurate than MELD in this group of patients.http://www.sciencedirect.com/science/article/pii/S1665268119314188CirrhosisModel for end-stage liver diseaseCreatinine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maiara Isabel Musskopf Fabricio Pimentel Fonseca Jeferson Gass Angelo Zambam de Mattos Jorge Alberto John Ajacio Bandeira de Mello Brandao, M.D. |
spellingShingle |
Maiara Isabel Musskopf Fabricio Pimentel Fonseca Jeferson Gass Angelo Zambam de Mattos Jorge Alberto John Ajacio Bandeira de Mello Brandao, M.D. Prognostic factors associated with in-hospital mortality in patients with spontaneous bacterial peritonitis Annals of Hepatology Cirrhosis Model for end-stage liver disease Creatinine |
author_facet |
Maiara Isabel Musskopf Fabricio Pimentel Fonseca Jeferson Gass Angelo Zambam de Mattos Jorge Alberto John Ajacio Bandeira de Mello Brandao, M.D. |
author_sort |
Maiara Isabel Musskopf |
title |
Prognostic factors associated with in-hospital mortality in patients with spontaneous bacterial peritonitis |
title_short |
Prognostic factors associated with in-hospital mortality in patients with spontaneous bacterial peritonitis |
title_full |
Prognostic factors associated with in-hospital mortality in patients with spontaneous bacterial peritonitis |
title_fullStr |
Prognostic factors associated with in-hospital mortality in patients with spontaneous bacterial peritonitis |
title_full_unstemmed |
Prognostic factors associated with in-hospital mortality in patients with spontaneous bacterial peritonitis |
title_sort |
prognostic factors associated with in-hospital mortality in patients with spontaneous bacterial peritonitis |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2012-11-01 |
description |
Introduction. Spontaneous bacterial peritonitis (SBP) is associated with a high in-hospital mortality rate ranging from 20-40%. The model for end-stage liver disease (MELD) has been suggested as a predictor of inhospital mortality in patients with SBP. However, the accuracy of the MELD has been questioned, and the integrated MELD (iMELD) score, which incorporates age and serum sodium to the previous model, has been proposed to improve prognostic accuracy. The iMELD has not yet been evaluated in patients with SBP.Aim. To evaluate the accuracy of iMELD and MELD scores in predicting in-hospital mortality in patients with SBP and to identify other prognostic factors of mortality in this group of patients.Results. Of 40 patients analyzed, 65% were male, 50% had hepatitis C, and 27.5% had hepatocellular carcinoma. Mean age was 55.6 years; 25.7% were classified as Child-Pugh class B, and 74.3% as class C. Mean scores were 46.0 and 19.9 for iMELD and MELD, respectively. In-hospital mortality was 40%. Univariate analysis showed that total bilirubin, creatinine, MELD and iMELD scores were significantly associated with in-hospital mortality. The prognostic accuracy was 80% and 77% for iMELD and MELD scores, respectively.Conclusion. In conclusion, bilirubin, creatinine, MELD and iMELD were predictors of in-hospital mortality in cirrhotic patients with SPB. iMELD was slightly more accurate than MELD in this group of patients. |
topic |
Cirrhosis Model for end-stage liver disease Creatinine |
url |
http://www.sciencedirect.com/science/article/pii/S1665268119314188 |
work_keys_str_mv |
AT maiaraisabelmusskopf prognosticfactorsassociatedwithinhospitalmortalityinpatientswithspontaneousbacterialperitonitis AT fabriciopimentelfonseca prognosticfactorsassociatedwithinhospitalmortalityinpatientswithspontaneousbacterialperitonitis AT jefersongass prognosticfactorsassociatedwithinhospitalmortalityinpatientswithspontaneousbacterialperitonitis AT angelozambamdemattos prognosticfactorsassociatedwithinhospitalmortalityinpatientswithspontaneousbacterialperitonitis AT jorgealbertojohn prognosticfactorsassociatedwithinhospitalmortalityinpatientswithspontaneousbacterialperitonitis AT ajaciobandeirademellobrandaomd prognosticfactorsassociatedwithinhospitalmortalityinpatientswithspontaneousbacterialperitonitis |
_version_ |
1721388717690585088 |