Hyperoxia exposure impairs nephrogenesis in the neonatal rat: role of HIF-1α.

Hyperoxia exposure impairs nephrogenesis in the neonatal rat: role of HIF-1α.

Preterm neonates are exposed at birth to high oxygen concentrations relative to the intrauterine environment. We have previously shown in a rat model that a hyperoxic insult results in a reduced nephron number in adulthood. Therefore, the aim of this study was to determine the effects of transient n...

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Bibliographic Details
Main Authors: Constantin R Popescu, Megan R Sutherland, Anik Cloutier, Geneviève Benoît, Mariane Bertagnolli, Catherine Yzydorczyk, Nathalie Germain, Véronique Phan, Martine Lelièvre-Pegorier, Hervé Sartelet, Anne Monique Nuyt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3866112?pdf=render

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http://europepmc.org/articles/PMC3866112?pdf=render

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