Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether enhancing the ISR can improve remyelination in an infla...

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Bibliographic Details
Main Authors: Yanan Chen, Rejani B Kunjamma, Molly Weiner, Jonah R Chan, Brian Popko
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
integrated stress response
remyelination
interferon gamma
oligodendrocyte
cuprizone
multiple sclerosis
Online Access:https://elifesciences.org/articles/65469

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