Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy
Recently, cancer immunotherapy has received attention as a viable solution for the treatment of refractory tumors. However, it still has clinical limitations in its treatment efficacy due to inter-patient tumor heterogeneity and immunosuppressive tumor microenvironment (TME). In this study, we demon...
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doaj-7598ac6d05a94ea8827758355792e04f2020-11-25T04:02:56ZengMDPI AGCancers2072-66942020-10-01123123312310.3390/cancers12113123Combination of Irreversible Electroporation and STING Agonist for Effective Cancer ImmunotherapyEun-Jin Go0Hannah Yang1Hong Jae Chon2DaSom Yang3WonHyoung Ryu4Dong-Hyun Kim5Dong Keun Han6Chan Kim7Wooram Park8Department of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-Si, Gyeonggi-do 14662, KoreaMedical Oncology, CHA Bundang Medical Center, CHA University School of Medicine, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13496, KoreaMedical Oncology, CHA Bundang Medical Center, CHA University School of Medicine, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13496, KoreaDepartment of Mechanical Engineering, Yonsei University, Seoul 03722, KoreaDepartment of Mechanical Engineering, Yonsei University, Seoul 03722, KoreaDepartment of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, KoreaMedical Oncology, CHA Bundang Medical Center, CHA University School of Medicine, 59 Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13496, KoreaDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-Si, Gyeonggi-do 14662, KoreaRecently, cancer immunotherapy has received attention as a viable solution for the treatment of refractory tumors. However, it still has clinical limitations in its treatment efficacy due to inter-patient tumor heterogeneity and immunosuppressive tumor microenvironment (TME). In this study, we demonstrated the triggering of anti-cancer immune responses by a combination of irreversible electroporation (IRE) and a stimulator of interferon genes (STING) agonist. Optimal electrical conditions inducing damage-associated molecular patterns (DAMPs) by immunogenic cell death (ICD) were determined through in vitro 2D and 3D cell experiments. In the in vivo syngeneic lung cancer model, the combination of IRE and STING agonists demonstrated significant tumor growth inhibition. We believe that the combination strategy of IRE and STING agonists has potential for effective cancer immunotherapy.https://www.mdpi.com/2072-6694/12/11/3123cancer immunotherapyirreversible electroporation (IRE)stimulator of IFN genes (STING) agonistsimmunogenic cell death (ICD)combinational treatment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eun-Jin Go Hannah Yang Hong Jae Chon DaSom Yang WonHyoung Ryu Dong-Hyun Kim Dong Keun Han Chan Kim Wooram Park |
spellingShingle |
Eun-Jin Go Hannah Yang Hong Jae Chon DaSom Yang WonHyoung Ryu Dong-Hyun Kim Dong Keun Han Chan Kim Wooram Park Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy Cancers cancer immunotherapy irreversible electroporation (IRE) stimulator of IFN genes (STING) agonists immunogenic cell death (ICD) combinational treatment |
author_facet |
Eun-Jin Go Hannah Yang Hong Jae Chon DaSom Yang WonHyoung Ryu Dong-Hyun Kim Dong Keun Han Chan Kim Wooram Park |
author_sort |
Eun-Jin Go |
title |
Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy |
title_short |
Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy |
title_full |
Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy |
title_fullStr |
Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy |
title_full_unstemmed |
Combination of Irreversible Electroporation and STING Agonist for Effective Cancer Immunotherapy |
title_sort |
combination of irreversible electroporation and sting agonist for effective cancer immunotherapy |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-10-01 |
description |
Recently, cancer immunotherapy has received attention as a viable solution for the treatment of refractory tumors. However, it still has clinical limitations in its treatment efficacy due to inter-patient tumor heterogeneity and immunosuppressive tumor microenvironment (TME). In this study, we demonstrated the triggering of anti-cancer immune responses by a combination of irreversible electroporation (IRE) and a stimulator of interferon genes (STING) agonist. Optimal electrical conditions inducing damage-associated molecular patterns (DAMPs) by immunogenic cell death (ICD) were determined through in vitro 2D and 3D cell experiments. In the in vivo syngeneic lung cancer model, the combination of IRE and STING agonists demonstrated significant tumor growth inhibition. We believe that the combination strategy of IRE and STING agonists has potential for effective cancer immunotherapy. |
topic |
cancer immunotherapy irreversible electroporation (IRE) stimulator of IFN genes (STING) agonists immunogenic cell death (ICD) combinational treatment |
url |
https://www.mdpi.com/2072-6694/12/11/3123 |
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