The current aetiology of malignant pleural effusion in the Western Cape Province South Africa
Background. Malignant pleural effusion (MPE) represents a very common cause of pleural exudates, and is one of the most challenging pleural disorders to manage. This could be attributed to the paucity of high-quality experimental evidence, and inconsistent practice worldwide. South Africa (SA) curre...
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doaj-759a4427836442df901464e3c9170a4e2020-11-25T00:05:47ZengHealth and Medical Publishing GroupSouth African Medical Journal0256-95742078-51352018-03-01108427527710.7196/SAMJ.2018.v108i4.12936The current aetiology of malignant pleural effusion in the Western Cape Province South AfricaC KoegelenbergS BennjiE BoerP SchubertJ ShawB AllwoodE IrusenBackground. Malignant pleural effusion (MPE) represents a very common cause of pleural exudates, and is one of the most challenging pleural disorders to manage. This could be attributed to the paucity of high-quality experimental evidence, and inconsistent practice worldwide. South Africa (SA) currently has no data regarding the aetiology of MPE.Objectives. To identify the most common malignancies causing MPE in a population served by a large tertiary hospital in SA, and specifically the relative contribution of mesothelioma. A secondary objective was to evaluate the efficacy of chemical pleurodesis in a subset of patients.Methods. We retrospectively included all known cases of MPE evaluated at our institution over a 3-year period with a tissue diagnosis of MPE.Results. The most common causes of MPE in a total of 274 patients were lung cancer (n=174, 63.5%), breast cancer (n=32, 11.7%), unknown primary (n=22, 11.7%) and mesothelioma (n=27, 9.9%). Talc pleurodesis was performed in 81 of 194 patients (41.8%) referred to our division, and was radiologically successful in 22 of 25 (88.0%) followed up to 3 months.Conclusions. The main cause of MPE in our setting was lung cancer, followed by breast cancer, unknown primary and mesothelioma. Chemical pleurodesis was a viable palliative measure for MPE in this population.http://www.samj.org.za/index.php/samj/article/download/12262/8445 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
C Koegelenberg S Bennji E Boer P Schubert J Shaw B Allwood E Irusen |
spellingShingle |
C Koegelenberg S Bennji E Boer P Schubert J Shaw B Allwood E Irusen The current aetiology of malignant pleural effusion in the Western Cape Province South Africa South African Medical Journal |
author_facet |
C Koegelenberg S Bennji E Boer P Schubert J Shaw B Allwood E Irusen |
author_sort |
C Koegelenberg |
title |
The current aetiology of malignant pleural effusion in the Western Cape Province South Africa |
title_short |
The current aetiology of malignant pleural effusion in the Western Cape Province South Africa |
title_full |
The current aetiology of malignant pleural effusion in the Western Cape Province South Africa |
title_fullStr |
The current aetiology of malignant pleural effusion in the Western Cape Province South Africa |
title_full_unstemmed |
The current aetiology of malignant pleural effusion in the Western Cape Province South Africa |
title_sort |
current aetiology of malignant pleural effusion in the western cape province south africa |
publisher |
Health and Medical Publishing Group |
series |
South African Medical Journal |
issn |
0256-9574 2078-5135 |
publishDate |
2018-03-01 |
description |
Background. Malignant pleural effusion (MPE) represents a very common cause of pleural exudates, and is one of the most challenging pleural disorders to manage. This could be attributed to the paucity of high-quality experimental evidence, and inconsistent practice worldwide. South Africa (SA) currently has no data regarding the aetiology of MPE.Objectives. To identify the most common malignancies causing MPE in a population served by a large tertiary hospital in SA, and specifically the relative contribution of mesothelioma. A secondary objective was to evaluate the efficacy of chemical pleurodesis in a subset of patients.Methods. We retrospectively included all known cases of MPE evaluated at our institution over a 3-year period with a tissue diagnosis of MPE.Results. The most common causes of MPE in a total of 274 patients were lung cancer (n=174, 63.5%), breast cancer (n=32, 11.7%), unknown primary (n=22, 11.7%) and mesothelioma (n=27, 9.9%). Talc pleurodesis was performed in 81 of 194 patients (41.8%) referred to our division, and was radiologically successful in 22 of 25 (88.0%) followed up to 3 months.Conclusions. The main cause of MPE in our setting was lung cancer, followed by breast cancer, unknown primary and mesothelioma. Chemical pleurodesis was a viable palliative measure for MPE in this population. |
url |
http://www.samj.org.za/index.php/samj/article/download/12262/8445 |
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