In vivo wound healing and antiulcer properties of white sweet potato (Ipomoea batatas)
The potential of tuber flour of Ipomoea batatas (L.) Lam. cv. Brazlândia Branca (white sweet potato) as wound healing and antiulcerogenic agent was investigated in vivo in animal model. Excision on the back of Wistar rats was performed to induce wounds that were topically treated with Beeler’s base...
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doaj-759c7df15bce4804ac066856887e84552020-11-25T00:04:03ZengElsevierJournal of Advanced Research2090-12322090-12242013-07-014441141510.1016/j.jare.2012.06.001In vivo wound healing and antiulcer properties of white sweet potato (Ipomoea batatas)Daniele Hermes0Débora N. Dudek1Mariana D. Maria2Lívia P. Horta3Eliete N. Lima4Ângelo de Fátima5Andréia C.C. Sanches6Luzia V. Modolo7Centro de Ciências Médicas e Farmacêuticas, Universidade Estadual do Oeste do Paraná, Cascavel, PR, BrazilCentro de Ciências Médicas e Farmacêuticas, Universidade Estadual do Oeste do Paraná, Cascavel, PR, BrazilCentro de Ciências Médicas e Farmacêuticas, Universidade Estadual do Oeste do Paraná, Cascavel, PR, BrazilDepartamento de Botânica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilFaculdade Regional do Vale do Aço, Universidade Presidente Antônio Carlos, Ipatinga, MG, BrazilDepartamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilCentro de Ciências Médicas e Farmacêuticas, Universidade Estadual do Oeste do Paraná, Cascavel, PR, BrazilDepartamento de Botânica, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil The potential of tuber flour of Ipomoea batatas (L.) Lam. cv. Brazlândia Branca (white sweet potato) as wound healing and antiulcerogenic agent was investigated in vivo in animal model. Excision on the back of Wistar rats was performed to induce wounds that were topically treated with Beeler’s base containing tuber flour of white sweet potato at 2.5%. Number of cells undergoing metaphase and the degree of tissue re-epithelialization were investigated 4, 7 and 10 days post-treatment. The protective effect of aqueous suspension of tuber flour (75 and 100 mg/kg animal weight) on gastric mucosa of Wistar rats was also studied by using the ethanol-induced ulceration model. Ointment based on white sweet potato at 2.5% effectively triggered the healing of cutaneous wound as attested by the increased number of cells undergoing metaphase and tissue re-epithelialization regardless the time of wound treatment. Tuber flour potentially prevented ethanol-induced gastric ulceration by suppressing edema formation and partly protecting gastric mucosa wrinkles. Crude extracts also exhibited potential as free radical scavengers. The results from animal model experiments indicate the potential of tuber flour of white sweet potato to heal wounds. http://www.sciencedirect.com/science/article/pii/S2090123212000471White sweet potatoIpomoea batatasWound healingRe-epithelializationUlceration indexFree radical scavenging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniele Hermes Débora N. Dudek Mariana D. Maria Lívia P. Horta Eliete N. Lima Ângelo de Fátima Andréia C.C. Sanches Luzia V. Modolo |
spellingShingle |
Daniele Hermes Débora N. Dudek Mariana D. Maria Lívia P. Horta Eliete N. Lima Ângelo de Fátima Andréia C.C. Sanches Luzia V. Modolo In vivo wound healing and antiulcer properties of white sweet potato (Ipomoea batatas) Journal of Advanced Research White sweet potato Ipomoea batatas Wound healing Re-epithelialization Ulceration index Free radical scavenging |
author_facet |
Daniele Hermes Débora N. Dudek Mariana D. Maria Lívia P. Horta Eliete N. Lima Ângelo de Fátima Andréia C.C. Sanches Luzia V. Modolo |
author_sort |
Daniele Hermes |
title |
In vivo wound healing and antiulcer properties of white sweet potato (Ipomoea batatas) |
title_short |
In vivo wound healing and antiulcer properties of white sweet potato (Ipomoea batatas) |
title_full |
In vivo wound healing and antiulcer properties of white sweet potato (Ipomoea batatas) |
title_fullStr |
In vivo wound healing and antiulcer properties of white sweet potato (Ipomoea batatas) |
title_full_unstemmed |
In vivo wound healing and antiulcer properties of white sweet potato (Ipomoea batatas) |
title_sort |
in vivo wound healing and antiulcer properties of white sweet potato (ipomoea batatas) |
publisher |
Elsevier |
series |
Journal of Advanced Research |
issn |
2090-1232 2090-1224 |
publishDate |
2013-07-01 |
description |
The potential of tuber flour of Ipomoea batatas (L.) Lam. cv. Brazlândia Branca (white sweet potato) as wound healing and antiulcerogenic agent was investigated in vivo in animal model. Excision on the back of Wistar rats was performed to induce wounds that were topically treated with Beeler’s base containing tuber flour of white sweet potato at 2.5%. Number of cells undergoing metaphase and the degree of tissue re-epithelialization were investigated 4, 7 and 10 days post-treatment. The protective effect of aqueous suspension of tuber flour (75 and 100 mg/kg animal weight) on gastric mucosa of Wistar rats was also studied by using the ethanol-induced ulceration model. Ointment based on white sweet potato at 2.5% effectively triggered the healing of cutaneous wound as attested by the increased number of cells undergoing metaphase and tissue re-epithelialization regardless the time of wound treatment. Tuber flour potentially prevented ethanol-induced gastric ulceration by suppressing edema formation and partly protecting gastric mucosa wrinkles. Crude extracts also exhibited potential as free radical scavengers. The results from animal model experiments indicate the potential of tuber flour of white sweet potato to heal wounds.
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topic |
White sweet potato Ipomoea batatas Wound healing Re-epithelialization Ulceration index Free radical scavenging |
url |
http://www.sciencedirect.com/science/article/pii/S2090123212000471 |
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