Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patients
Activation of proinflammatory cytokines in seizures has been well characterized. However, role of cytokines in epilepsy and association with different clinical phenotype has not been well investigated. Reports on possible link between proinflammatory molecules and epilepsy are very limited. In this...
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doaj-75a3899cd6844354883b341486eab2c72020-11-25T02:50:42ZengSAGE PublishingEuropean Journal of Inflammation2058-73922018-05-011610.1177/2058739218778934Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patientsLi XiaSong-Qing PanQiu-Min ZhangQin ZhouLu XiaZu-Neng LuActivation of proinflammatory cytokines in seizures has been well characterized. However, role of cytokines in epilepsy and association with different clinical phenotype has not been well investigated. Reports on possible link between proinflammatory molecules and epilepsy are very limited. In this study, we performed a hospital-based case control study to investigate the association of plasma cytokines and their expression with different clinical categories of epilepsy. Patients admitted to Neurology Department of Renmin Hospital were enrolled in this study after clinical investigations. In all, 92 patients with temporal lobe epilepsy (TLE) and 45 with extra-temporal lobe epilepsy (XTLE) were included in this study. Furthermore, we included 86 healthy controls from the similar geographical population. Plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β were quantified by enzyme-linked immunosorbent assay (ELISA). All plasma cytokines were elevated in TLE and XTLE compared to healthy controls ( P < 0.0001). Furthermore, IL-6 and IL-1β were significantly higher in TLE when compared to extra-temporal epilepsy. Incidentally, no difference in mean plasma TNF-α levels was noticed among TLE and XTLE. Positive correlations were observed between all plasma proinflammatory molecules (TNF-α, IL-6, and IL-1β) investigated in this study. Epilepsy patients displayed higher proinflammatory molecules, namely, IL-6, IL-1β, and TNF-α. Plasma IL-6 and IL-1β can be use as biomarkers for differentiation of TLE from XTLE.https://doi.org/10.1177/2058739218778934 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li Xia Song-Qing Pan Qiu-Min Zhang Qin Zhou Lu Xia Zu-Neng Lu |
spellingShingle |
Li Xia Song-Qing Pan Qiu-Min Zhang Qin Zhou Lu Xia Zu-Neng Lu Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patients European Journal of Inflammation |
author_facet |
Li Xia Song-Qing Pan Qiu-Min Zhang Qin Zhou Lu Xia Zu-Neng Lu |
author_sort |
Li Xia |
title |
Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patients |
title_short |
Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patients |
title_full |
Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patients |
title_fullStr |
Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patients |
title_full_unstemmed |
Elevated IL-6 and IL-1β are associated with temporal lobe epilepsy: A study in Chinese patients |
title_sort |
elevated il-6 and il-1β are associated with temporal lobe epilepsy: a study in chinese patients |
publisher |
SAGE Publishing |
series |
European Journal of Inflammation |
issn |
2058-7392 |
publishDate |
2018-05-01 |
description |
Activation of proinflammatory cytokines in seizures has been well characterized. However, role of cytokines in epilepsy and association with different clinical phenotype has not been well investigated. Reports on possible link between proinflammatory molecules and epilepsy are very limited. In this study, we performed a hospital-based case control study to investigate the association of plasma cytokines and their expression with different clinical categories of epilepsy. Patients admitted to Neurology Department of Renmin Hospital were enrolled in this study after clinical investigations. In all, 92 patients with temporal lobe epilepsy (TLE) and 45 with extra-temporal lobe epilepsy (XTLE) were included in this study. Furthermore, we included 86 healthy controls from the similar geographical population. Plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β were quantified by enzyme-linked immunosorbent assay (ELISA). All plasma cytokines were elevated in TLE and XTLE compared to healthy controls ( P < 0.0001). Furthermore, IL-6 and IL-1β were significantly higher in TLE when compared to extra-temporal epilepsy. Incidentally, no difference in mean plasma TNF-α levels was noticed among TLE and XTLE. Positive correlations were observed between all plasma proinflammatory molecules (TNF-α, IL-6, and IL-1β) investigated in this study. Epilepsy patients displayed higher proinflammatory molecules, namely, IL-6, IL-1β, and TNF-α. Plasma IL-6 and IL-1β can be use as biomarkers for differentiation of TLE from XTLE. |
url |
https://doi.org/10.1177/2058739218778934 |
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